贝壳杉双芹素 | 28441-98-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 贝壳杉双芹素
• 英文名称: agathisflavone
• 英文别名: 8-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-6-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
• CAS: 28441-98-7
• 化学式: C₃₀H₁₈O₁₀
• 分子量: 538.467
• InChiKey: BACLASYRJRZXMY-UHFFFAOYSA-N

物化性质

• 沸点：
  929.1±65.0 °C(Predicted)
• 密度：
  1.656±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  40
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  174
• 氢给体数：
  6
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  贝壳杉双芹素 在 吡啶 作用下， 以 乙醚 为溶剂， 生成 5-acetyl-7,4'-dimethoxyflavone-(6-8'')-5''-acetyl-7'',4'''-dimethoxyflavone
  参考文献：
  名称：

  一种新的琼脂黄酮衍生物的碳 13 和质子 NMR 分配

  摘要：

  5-乙酰基-7,4'-二甲氧基黄酮-(6-8″)-5″-乙酰基-7″,4‴-二甲氧基黄酮是一种新的agathis黄酮衍生物的1H和13C NMR谱完全基于一维和二维核磁共振技术。版权所有 © 2005 John Wiley & Sons, Ltd.

  DOI：

  10.1002/mrc.1720

文献信息

• Amentoflavone as an antiviral agent
  申请人：Advanced Life Sciences Inc.

  公开号：EP1245230A2

  公开（公告）日：2002-10-02

  Substantially purified antiviral biflavanoids robustaflavone, hinokiflavone, amentoflavone, agathisflavone, volkensiflavone, morelloflavone, rhusflavanone, succedaneaflavanone, GB-1a and GB-2a are provided. Antiviral fiflavanoid derivatives and salt forms thereof, e.g. robustaflavone tetrasulfate potassium salt, and methods for preparing the same are also disclosed. Pharmaceutical compositions which include the antiviral biflavanoids, derivatives or salts thereof are also provided. Also disclosed is an improved method for obtaining substantially pure robustaflavone from plant material. The biflavanoid compounds, derivatives or salts thereof of the invention may be used in a method for treating and/or preventing viral infections caused by viral agents such as influenza, e.g. influenza A and B; hepatitis, e.g. hepatitis B; human immunodeficiency virus, e.g. HIV-1; Herpes viruses (HSV-1 and HSV-2); Varicella Zoster virus (VZV); and measles.

  本研究提供了实质上纯化的抗病毒双黄酮类化合物--强力黄酮、桧黄酮、芒果黄酮、芒果黄酮、伏肯黄酮、麦卢黄酮、胡黄酮、琥珀黄酮、GB-1a 和 GB-2a。此外，还公开了抗病毒的五黄烷衍生物及其盐形式，例如强力黄酮四硫酸钾盐，以及制备方法。还提供了包括抗病毒双黄烷、衍生物或其盐的药物组合物。此外，还公开了一种从植物材料中获得高纯度强力黄酮的改进方法。本发明的双黄烷化合物、衍生物或其盐类可用于治疗和/或预防由病毒病原体引起的病毒感染，如流感，如甲型和乙型流感；肝炎，如乙型肝炎；人类免疫缺陷病毒，如 HIV-1；疱疹病毒（HSV-1 和 HSV-2）；水痘带状疱疹病毒（VZV）；以及麻疹。
• Botanical extracts and compounds from schinus plants and methods of use
  申请人：Emory University

  公开号：US10675315B2

  公开（公告）日：2020-06-09

  This disclosure relates to extracts from the Anacardiaceae (cashew plant family) and compositions comprising compounds contained therein. In certain embodiments, the extracts are derived from the fruit of a Schinus plant. In certain embodiments, the disclosure relates to methods of treating or preventing bacterial infections, acne, and other related uses.

  本公开涉及腰果科（Anacardiaceae）植物的提取物和包含其中所含化合物的组合物。在某些实施方案中，这些提取物来源于Schinus植物的果实。在某些实施方案中，本公开涉及治疗或预防细菌感染、痤疮及其他相关用途的方法。
• Botanical extracts and compounds from Schinus plants and methods of use
  申请人：Emory University

  公开号：US11065261B2

  公开（公告）日：2021-07-20

  This disclosure relates to extracts from the Anacardiaceae (cashew plant family) and compositions comprising compounds contained therein. In certain embodiments, the extracts are derived from the fruit of a Schinus plant. In certain embodiments, the disclosure relates to methods of treating or preventing bacterial infections, acne, and other related uses.

  本公开涉及腰果科（Anacardiaceae）植物的提取物和包含其中所含化合物的组合物。在某些实施方案中，这些提取物来源于Schinus植物的果实。在某些实施方案中，本公开涉及治疗或预防细菌感染、痤疮及其他相关用途的方法。
• Biflavanoids and derivatives thereof as antiviral agents
  申请人：Advanced Life Sciences, Inc.

  公开号：US20020068757A1

  公开（公告）日：2002-06-06

  Substantially purified antiviral biflavanoids robustaflavone, hinokiflavone, amentoflavone, agathisflavone, volkensiflavone, morelloflavone, rhusflavanone, succedaneaflavanone, GB-1a, and GB-2a are provided. Antiviral biflavanoid derivatives and salt forms thereof, e.g., robustaflavone tetrasulfate potassium salt, and methods for preparing the same are also disclosed. Pharmaceutical compositions which include the antiviral biflavanoids, derivatives or salts thereof are also provided alone or in combination with at least one antiviral agent such as 3TC. Also disclosed is an improved method for obtaining substantially pure robustaflavone from plant material. The biflavanoid compounds, derivatives or salts thereof of the invention may be used in a method for treating and/or preventing viral infections caused by viral agents such as influenza, e.g., influenza A and B; hepatitis, e.g., hepatitis B; human immunodeficiency virus, e.g., HIV-1; Herpes viruses (HSV-1 and HSV-2); Varicella Zoster virus (VZV); and measles. For instance, semi-synthetic hexa-O-acetate and hexa-O-methyl ether derivatives of robustaflavone have been found to be effective in a method for treating or preventing hepatitis B viral infections. Compositions which include these robustaflavone derivatives along with methods for preparing and using the same are also provided. These compositions may be used alone or in combination with at least one antiviral agent such as 3TC.

  本研究提供了实质上纯化的抗病毒双黄酮类物质--强力黄酮、桧黄酮、芒果黄酮、茄黄酮、伏肯黄酮、更萝黄酮、胡黄酮、琥珀黄酮、GB-1a 和 GB-2a。此外，还公开了抗病毒双黄烷衍生物及其盐形式，例如强力黄酮四硫酸钾盐，以及制备方法。还提供了包括抗病毒双黄酮类化合物、衍生物或其盐类的药物组合物，这些药物组合物可单独使用，也可与至少一种抗病毒药物如 3TC 结合使用。此外，还公开了一种从植物材料中获得高纯度强力黄酮的改进方法。本发明的双黄烷化合物、衍生物或其盐类可用于治疗和/或预防由病毒病原体引起的病毒感染，如流感，如甲型和乙型流感；肝炎，如乙型肝炎；人类免疫缺陷病毒，如HIV-1；疱疹病毒（HSV-1和HSV-2）；水痘带状疱疹病毒（VZV）；以及麻疹。例如，在治疗或预防乙型肝炎病毒感染的方法中，发现了半合成的六-O-乙酸酯和六-O-甲醚衍生物强力黄酮。此外，还提供了包括这些强力黄酮衍生物的组合物以及制备和使用这些组合物的方法。这些组合物可单独使用，也可与至少一种抗病毒药物如 3TC 结合使用。
• Composition and method for topical nail treatment
  申请人：——

  公开号：US20030091519A1

  公开（公告）日：2003-05-15

  The invention discloses a composition comprising a sulfur-containing glycine residue combined with urea to increase the permeation of an active agent or drug through human nail tissue. The invention further provides methods of applying the composition to a nail surface.

  本发明公开了一种包含含硫甘氨酸残基与尿素的组合物，可增加活性剂或药物通过人体指甲组织的渗透性。本发明进一步提供了将该组合物应用于指甲表面的方法。