N-Cyclooctylidene-N'-(4-phenyl-thiazol-2-yl)-hydrazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-Cyclooctylidene-N'-(4-phenyl-thiazol-2-yl)-hydrazine
• 英文别名: Cyclooctanone, (4-phenyl-2-thiazolyl)hydrazone；N-(cyclooctylideneamino)-4-phenyl-1,3-thiazol-2-amine
• 化学式: C₁₇H₂₁N₃S
• 分子量: 299.44
• InChiKey: ZUJBGKNKOBATEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  环辛酮 在 溶剂黄146 作用下， 以 异丙醇 为溶剂， 反应 1.0h， 生成 N-Cyclooctylidene-N'-(4-phenyl-thiazol-2-yl)-hydrazine
  参考文献：
  名称：

  Synthesis and anti-microbial activity of isothiosemicarbazones and cyclic analogues

  摘要：

  It is known that some derivatives of both thiourea and thiosemicarbazide exhibit potent anti-microbial activity. In order to investigate the effects on the biological properties of structural modifications of such structures, we have synthesised and studied some arylidenisothiosenticarbazones. In this paper we report on the synthesis and structure-activity relationships of some isothiosemicarbazones, where the arylidene group has been replaced with a cycloalkyl group and the sulfur atom has been either differently substituted or enclosed in a thiazole ring. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

  DOI：

  10.1016/s0014-827x(02)01288-0