1-[5-(1(3)H-imidazol-4-yl)-pentyl]-3-methyl-thiourea | 34042-45-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[5-(1(3)H-imidazol-4-yl)-pentyl]-3-methyl-thiourea
• 英文别名: 1-[5-(1H-imidazol-5-yl)pentyl]-3-methylthiourea
• CAS: 34042-45-0
• 化学式: C₁₀H₁₈N₄S
• 分子量: 226.346
• InChiKey: BHXVXFKQYAHZKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  84.8
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  异硫氰酸甲酯 、 Impentamine dihydrobromide 在 sodium ethanolate 作用下， 生成 1-[5-(1(3)H-imidazol-4-yl)-pentyl]-3-methyl-thiourea
  参考文献：
  名称：

  New Analogs of Burimamide as Potent and Selective Histamine H3 Receptor Antagonists: The Effect of Chain Length Variation of the Alkyl Spacer and Modifications of the N-Thiourea Substituent

  摘要：

  Burimamide was one of the first compounds reported to antagonize the activation of the histamine H-3 receptor by histamine. We have prepared a large series of burimamide analogs by variation of the alkyl spacer length of burimamide from two methylene groups to six methylene groups and also by replacement of the N-methyl group with other alkyl and aryl groups. All analogs are reversible, competitive H-3 antagonists as determined on the guinea pig intestine. Elongation of the alkyl chain from an ethylene chain to a hexylene chain results in an increase of the H-3 antagonistic activity. The H-3 selective pentylene and hexylene analogs of burimamide are about 10 times more potent than burimamide. The N-thiourea substituents, however, have no beneficial influence on the affinity.

  DOI：

  10.1021/jm00012a025

文献信息

• US4189488A
  申请人：——

  公开号：US4189488A

  公开（公告）日：1980-02-19
• US4308275A
  申请人：——

  公开号：US4308275A

  公开（公告）日：1981-12-29
• US4395419A
  申请人：——

  公开号：US4395419A

  公开（公告）日：1983-07-26
• US4438127A
  申请人：——

  公开号：US4438127A

  公开（公告）日：1984-03-20