2-fluoro-1,4-diazaspiro[4.5]decan-8-one | 196953-80-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-fluoro-1,4-diazaspiro[4.5]decan-8-one
• 英文别名: 7-Fluoro-1,4-dioxaspiro[4.5]decan-8-one；7-fluoro-1,4-dioxaspiro[4.5]decan-8-one
• CAS: 196953-80-7
• 化学式: C₈H₁₁FO₃
• 分子量: 174.172
• InChiKey: NRPFDYDTOGVMQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 Selectfluor 作用下， 以 乙腈 为溶剂， 生成 2-fluoro-1,4-diazaspiro[4.5]decan-8-one
  参考文献：
  名称：

  Enantioselective Organocatalytic α-Fluorination of Cyclic Ketones

  摘要：

  The first highly enantioselective alpha-fluorination of ketones using organocatalysis has been accomplished. The long-standing problem of enantioselective ketone alpha-fluorination via enamine activation has been overcome via high-throughput evaluation of a new library of amine catalysts. The optimal system, a primary amine functionalized Cinchona alkaloid, allows the direct and asymmetric a-fluorination of a variety of carbo- and heterocyclic substrates. Furthermore, this protocol also provides diastereo-, regio-, and chemoselective catalyst control in fluorinations involving complex carbonyl systems.

  DOI：

  10.1021/ja111163u