2-羟基-6-甲基苯磺酸 | 69103-65-7

• 物质功能分类: 化学试剂 - 有机试剂
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-羟基-6-甲基苯磺酸
• 英文名称: 3-methylphenol-2-sulphonic acid
• 英文别名: 2-Hydroxy-6-methyl-benzolsulfonsaeure；2-hydroxy-6-methyl-benzenesulfonic acid；2-Hydroxy-6-methylbenzenesulfonic acid
• CAS: 69103-65-7
• 化学式: C₇H₈O₄S
• 分子量: 188.204
• InChiKey: ODLIHNXQTJXBDT-UHFFFAOYSA-N

物化性质

• 密度：
  1.482±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  83
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-羟基-6-甲基苯磺酸 在 硫酸 作用下， 生成 4-羟基-2-甲基苯磺酸铵 、 5-甲基苯酚-2-磺酸钙 、 4-Hydroxy-2-methyl-benzene-1,3-disulfonic acid
  参考文献：
  名称：

  Lambrechts, Hans J. A.; Schaasberg-Nienhuis, Zwaan R. H.; Cerfontain, Hans, Journal of the Chemical Society. Perkin transactions II, 1985, p. 669 - 676

  摘要：

  DOI：
• 作为产物：
  描述：

  间甲酚 、 氯磺酸 以11%的产率得到
  参考文献：
  名称：

  STRANDLUND G.; LAGERSTRAM P. O., ACTA CHEM. SCAND., 1979, B33, NO 4, 261-264

  摘要：

  DOI：

文献信息

• METHOD FOR THE HYDROXYLATION OF PHENOL
  申请人：Garel Laurent

  公开号：US20110152579A1

  公开（公告）日：2011-06-23

  The subject of the present invention is a method for the hydroxylation of phenol by hydrogen peroxide. The method of the invention for the hydroxylation of phenol to pyrocatechol and hydroquinone in a pyrocatechol/hydroquinone ratio between 1.7 and 2.3, by reaction of the phenol with hydrogen peroxide, in the presence of a catalyst, is characterized by the fact that the reaction is carried out in the presence of an effective amount of a hydroxyaromatic sulfonic acid.

  本发明的主题是一种利用过氧化氢对酚进行羟基化的方法。本发明的方法通过将酚与过氧化氢在催化剂的存在下反应，以在1.7至2.3的间隔内将酚羟基化为间苯二酚和对苯二酚，其特点在于反应在有效量的羟基芳香磺酸的存在下进行。
• Method for hydroxylating phenols and phenol ethers
  申请人：Garel Laurent

  公开号：US20140073818A1

  公开（公告）日：2014-03-13

  A method for hydroxylating phenols and phenol ethers using hydrogen peroxide and specifically, a method for hydroxylating phenol using hydrogen peroxide. The method for hydroxylating a phenolic substrate selected from a phenol or a phenol ether by reacting such phenolic substrate with hydrogen peroxide in the presence of an acid catalyst comprises the following steps, implemented consecutively or simultaneously: a first step consisting of mixing a phenolic substrate with a hydrogen peroxide solution under conditions in which the temperature is sufficient for the initial phenolic substrate to remain liquid and for minimizing the conversion rate of the hydrogen peroxide; a second step consisting of carrying out the phenolic substrate hydroxylation reaction under adiabatic conditions, the acid catalyst being added at the mixing stage and/or at the beginning of the hydroxylation reaction; and a third step, if necessary, consisting of recovering the hydroxylated product.

  使用过氧化氢进行酚和酚醚的羟基化的方法，特别是使用过氧化氢进行酚的羟基化的方法。通过在酸催化剂存在下，将酚或酚醚等酚类底物与过氧化氢反应进行羟基化反应的方法包括以下步骤，这些步骤可以依次或同时实施：第一步是在温度足以使初始酚类底物保持液态并最小化过氧化氢的转化率的条件下，将酚类底物与过氧化氢溶液混合；第二步是在绝热条件下进行酚类底物羟基化反应，酸催化剂在混合阶段和/或羟基化反应开始时加入；第三步，必要时，是回收羟基化产物。
• METHOD FOR THE HYDROXYLATION OF PHENOLS AND PHENOL ETHERS
  申请人：Garel Laurent

  公开号：US20140221698A1

  公开（公告）日：2014-08-07

  The present invention relates to a method for the hydroxylation of phenols and phenol ethers by means of hydrogen peroxide. The invention specifically relates to a method for the hydroxylation of phenol by means of the hydrogen peroxide. The method of the invention for the hydroxylation of a phenol ether by means of reacting said phenol or phenol ether with the hydrogen peroxide in the presence of an acid catalyst is characterized in that it includes mixing a phenol or phenol ether with a hydrogen peroxide solution in a mixing device under conditions enabling the conversion rate of the hydrogen peroxide to be minimized, and in that said reaction mixture is then placed in a piston flow reactor where the reaction leading to the production of the hydroxylated material takes place, the acid catalyst being fed into the mixing device and/or into the piston flow reactor.

  本发明涉及一种使用过氧化氢对苯酚和苯酚醚进行羟基化的方法。本发明具体涉及一种使用过氧化氢对苯酚进行羟基化的方法。本发明针对一种苯酚醚的羟基化方法，通过在酸性催化剂存在下，将所述苯酚或苯酚醚与过氧化氢反应，其特征在于将苯酚或苯酚醚与过氧化氢溶液在混合装置中混合，以使过氧化氢的转化率最小化，并且将该反应混合物放置在活塞流反应器中进行，产生羟基化物质的反应，酸性催化剂被加入到混合装置和/或活塞流反应器中。
• PROCESS FOR THE HYDROXYLATION OF PHENOLS AND OF PHENOL ETHERS
  申请人：Garel Laurent

  公开号：US20120035397A1

  公开（公告）日：2012-02-09

  A process for the hydroxylation of phenols and of phenol ethers by hydrogen peroxide is described. More particularly a process for the hydroxylation of phenol by hydrogen peroxide is described. The described process can include hydroxylation of a phenol or of a phenol ether having at least one hydrogen atom at the ortho and para position of the hydroxyl group or of the ether group, by reaction of said phenol or phenol ether, with hydrogen peroxide, in the presence of an acid catalyst, wherein the reaction is carried out in the presence of an effective amount of a catalyst which is a mixture of at least two strong acids and wherein one of the acids is chosen from strong protonic acids and the other acid is chosen from superacids.

  本文描述了一种使用过氧化氢对酚和酚醚进行羟基化的方法。更具体地，本文描述了一种使用过氧化氢对酚进行羟基化的方法。所述方法可以包括羟基化具有羟基或醚基的酚或酚醚，其在羟基或醚基的邻位和对位位置至少有一个氢原子，通过在酸催化剂的存在下，将所述酚或酚醚与过氧化氢反应，其中反应在有效量的催化剂存在下进行，所述催化剂是至少两个强酸的混合物，其中一个酸是选择自强质子酸，另一个酸是选择自超强酸。
• Method for the preparation of meta dihydroxybenzenes
  申请人：Koppers Company, Inc.

  公开号：US04009212A1

  公开（公告）日：1977-02-22

  A process for the preparation of dihydroxybenzenes whereby there are obtained primarily meta isomers of the dihydroxybenzenes includes the steps of: preparing a mixture of sulfonic acid isomers by sulfonation-isomerization of an hydroxybenzene having the formula: ##STR1## in which R and R' are selected from the group consisting of hydrogen and an alkyl radical having at most 4 carbon atoms per molecule, the total carbon atoms in radicals R and R' being at most 4; subjecting the so-produced sulfonic acids to selective hydrolyzation in aqueous medium at a temperature between about 100.degree. and 150.degree. C., the monohydroxy benzene being recovered by the said selective hydrolyzation in an enriched concentration that makes it readily recoverable by recycle in the process or other separation methods, and unhydrolyzed sulfonic acid remaining in the said aqueous medium; caustically fusing the said unhydrolyzed sulfonic acid, and liberating by acidification the desired dihydroxybenzene.

  一种制备二羟基苯的方法，其中主要获得二羟基苯的间位异构体，包括以下步骤：通过磺化-异构化反应制备羟基苯的异构体混合物，该羟基苯具有以下公式：##STR1## 其中R和R'选择自氢和每个分子中至多有4个碳原子的烷基基团的群体，基团R和R'中的总碳原子至多为4；在100℃至150℃之间的水介质中对所生产的磺酸进行选择性水解，单羟基苯通过所述选择性水解以富集的浓度回收，使其可以通过回收在过程中或其他分离方法中轻松回收，并且未水解的磺酸仍留在所述水介质中；碱性熔融所述未水解的磺酸，并通过酸化释放所需的二羟基苯。