9,9-dimethyl-10-(5-methyl-1-pyrrolin-2-yl)acridan | 56821-01-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9,9-dimethyl-10-(5-methyl-1-pyrrolin-2-yl)acridan
• 英文别名: 9,9-dimethyl-10-(2-methyl-3,4-dihydro-2H-pyrrol-5-yl)acridine
• CAS: 56821-01-3
• 化学式: C₂₀H₂₂N₂
• 分子量: 290.408
• InChiKey: GNXVCEUMQOTOTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  15.6
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  9,9-二甲基吖啶 、 5-甲基-2-吡咯烷酮 、 三氯氧磷 以provides the free base 9,9-DIMETHYL-10-(5-METHYL-1-PYRROLIN-2-YL)ACRIDAN as a distillable oil, b.p. 160-180° C. at 0.15 mm Hg的产率得到9,9-dimethyl-10-(5-methyl-1-pyrrolin-2-yl)acridan
  参考文献：
  名称：

  10-Imidoylacridans

  摘要：

  小说10-咪唑基苯氧噻嗪和10-咪唑基蒽醌是通过将具有三氟甲基、卤素、二卤素、烷基或烷氧等可选取代基的苯氧噻嗪或蒽醌与由酰胺和内酰胺制备的咪唑酰卤反应而制备的。其中的示例包括10-(5-甲基-1-吡咯烷-2-基)苯氧噻嗪和9,9-二甲基-10-(5-甲基-1-吡咯烷-2-基)蒽醌。咪唑基苯氧噻嗪和咪唑基蒽醌产品通常用作平滑肌松弛剂。

  公开号：

  US03962252A1

文献信息

• Smooth muscle relaxant process employing 10-imidoylphenoxazines
  申请人：Mead Johnson & Company

  公开号：US04046891A1

  公开（公告）日：1977-09-06

  Novel 10-imidoylphenoxazines and 10-imidoylacridans are prepared by reacting a phenoxazine or acridan having optional substituents selected from the group consisting of trifluoromethyl, halogen, dihalogen, alkyl or alkoxy with an imidoyl halide prepared in situ from amides and lactams. Illustrative embodiments are 10-(5-methyl-1-pyrrolin-2-yl)phenoxazine and 9,9-dimethyl-10-(5-methyl-1-pyrrolin-2-yl)acridan. The imidoylphenoxazines and imidoylacridan products are generally useful as smooth muscle relaxants.

  小说10-咪唑基苯氧噻嗪和10-咪唑基蒽醌是通过将具有三氟甲基、卤素、二卤代、烷基或烷氧等可选取代基的苯氧噻嗪或蒽醌与由酰胺和内酰胺在原位制备的咪唑酰卤反应制备而成。示例包括10-(5-甲基-1-吡咯烷-2-基)苯氧噻嗪和9,9-二甲基-10-(5-甲基-1-吡咯烷-2-基)蒽醌。咪唑基苯氧噻嗪和咪唑基蒽醌产品通常用作平滑肌松弛剂。
• Smooth muscle relaxant employing 10-imidoylacridans
  申请人：Mead Johnson & Company

  公开号：US04094981A1

  公开（公告）日：1978-06-13

  Novel 10-imidoylphenoxazines and 10-imidoylacridans are prepared by reacting a phenoxazine or acridan having optional substituents selected from the group consisting of trifluoromethyl, halogen, dihalogen, alkyl or alkoxy with an imidoyl halide prepared in situ from amides and lactams. Illustrative embodiments are 10-(5-methyl-1-pyrrolin-2-yl)phenoxazine and 9,9-dimethyl-10-(5-methyl-1-pyrrolin-2-yl)acridan. The imidoylphenoxazines and imidoylacridan products are generally useful as smooth muscle relaxants.

  小说10-咪唑基苯氧嗪和10-咪唑基蒽醌是通过将具有可选取代基的苯氧嗪或蒽醌与在位制备的酰亚胺卤化物反应而制备的，所述可选取代基选择自三氟甲基，卤素，二卤代，烷基或烷氧基。示例包括10-（5-甲基-1-吡咯烷-2-基）苯氧嗪和9,9-二甲基-10-（5-甲基-1-吡咯烷-2-基）蒽醌。咪唑基苯氧嗪和咪唑基蒽醌产品通常用作平滑肌松弛剂。
• 10-Imidoylacridan compositions
  申请人：Mead Johnson & Company

  公开号：US04132794A1

  公开（公告）日：1979-01-02

  Novel 10-imidoylphenoxazines and 10-imidoylacridans are prepared by reacting a phenoxazine or acridan having optional substituents selected from the group consisting of trifluoromethyl, halogen, dihalogen, alkyl or alkoxy with an imidoyl halide prepared in situ from amides and lactams. Illustrative embodiments are 10-(5-methyl-1-pyrrolin-2-yl)phenoxazine and 9,9-dimethyl-10-(5-methyl-1-pyrrolin-2-yl)acridan. The imidoylphenoxazines and imidoylacridan products are generally useful as smooth muscle relaxants.

  小说10-咪唑基苯并噻吩和10-咪唑基蒽醌是通过将具有三氟甲基、卤素、二卤代、烷基或烷氧等可选取代基的苯并噻吩或蒽醌与从酰胺和内酰胺中原位制备的咪唑基卤化物反应制备而成。示例包括10-(5-甲基-1-吡咯烷-2-基)苯并噻吩和9,9-二甲基-10-(5-甲基-1-吡咯烷-2-基)蒽醌。咪唑基苯并噻吩和咪唑基蒽醌产品通常用作平滑肌松弛剂。
• US3888852A
  申请人：——

  公开号：US3888852A

  公开（公告）日：1975-06-10
• US3962252A
  申请人：——

  公开号：US3962252A

  公开（公告）日：1976-06-08