9-(RS)-(2,3-dihydroxypropyl)hypoxanthine | 33514-46-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-(RS)-(2,3-dihydroxypropyl)hypoxanthine
• 英文别名: 9-(2',3'-Dihydroxypropyl)hypoxanthin；9-(2,3-dihydroxy-propyl)-1,9-dihydro-purin-6-one；1-(Hypoxanthine-9-yl)-2,3-propandiol；9-(2,3-dihydroxypropyl)-1H-purin-6-one
• CAS: 33514-46-4
• 化学式: C₈H₁₀N₄O₃
• 分子量: 210.192
• InChiKey: IIFAZDZRSYMVLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  99.7
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  9-(RS)-(2,3-dihydroxypropyl)hypoxanthine 在 4-二甲氨基吡啶 、 氯化亚砜 、 盐酸羟胺 、 sodium methylate 、 N,N-二甲基甲酰胺 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 11.0h， 生成 9-(RS)-(2,3-dihydroxypropyl)-6-hydroxylaminopurine
  参考文献：
  名称：

  Holy, Antonin; Rosenberg, Ivan; Dvorakova, Hana, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 9, p. 2470 - 2501

  摘要：

  DOI：
• 作为产物：
  描述：

  二羟丙基腺嘌呤 在 亚硝酸异戊酯 作用下， 以 水 、 溶剂黄146 为溶剂， 反应 48.0h， 以92%的产率得到9-(RS)-(2,3-dihydroxypropyl)hypoxanthine
  参考文献：
  名称：

  Holy, Antonin; Rosenberg, Ivan; Dvorakova, Hana, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 9, p. 2470 - 2501

  摘要：

  DOI：

文献信息

• Monomeric diols, phosphate linked oligomers formed therefrom and processes for preparing
  申请人：——

  公开号：US20030065146A1

  公开（公告）日：2003-04-03

  Novel ethylene glycol compounds bearing various functional groups are used to prepare oligomeric structures. The ethylene glycol monomers can be joined via standard phosphate linkages including phosphodiester and phosphorothioate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen-bonding.

  新型乙二醇化合物带有各种功能基团，用于制备寡聚体结构。乙二醇单体可以通过标准的磷酸酯和磷酸硫酯键连接。有用的功能基团包括核苷碱以及极性基团，疏水基团，离子基团，芳香基团和/或参与氢键的基团。
• Phosphate linked oligomers formed of monomeric diols and processes for preparing same
  申请人：ISIS Pharmaceuticals, Inc.

  公开号：US06448373B1

  公开（公告）日：2002-09-10

  Novel ethylene glycol compounds bearing various functional groups are used to prepare oligomeric structures. The ethylene glycol monomers can be joined via standard phosphate linkages including phosphodiester and phosphorothioate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen-bonding.

  新型乙二醇化合物带有各种功能基团，可用于制备寡聚物结构。乙二醇单体可以通过标准的磷酸酯键和磷酸硫酯键连接起来。有用的功能基团包括核碱基以及极性基团、亲水基团、离子基团、芳香基团和/或参与氢键的基团。
• Phosphate linked oligomers
  申请人：ISIS Pharmaceuticals, Inc.

  公开号：US05886177A1

  公开（公告）日：1999-03-23

  Novel ethylene glycol compounds bearing various functional groups are used to prepare oligomeric structures. The ethylene glycol monomers can be joined via standard phosphate linkages including phosphorothioate, phosphodiester, and phosphoramidate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen-bonding.

  新型含有不同功能基团的乙二醇化合物被用于制备寡聚体结构。乙二醇单体可以通过标准的磷酸酯键连接，包括硫代磷酸酯、磷酸二酯和磷酸酰胺键。有用的功能基团包括核碱基以及极性基团、疏水基团、离子基团、芳香基团和/或参与氢键的基团。
• HOLY, ANTONIN;ROSENBERG, IVAN
  作者：HOLY, ANTONIN、ROSENBERG, IVAN

  DOI：——

  日期：——
• MONOMERIC DIOLS AND PHOSPHATE LINKED OLIGOMERS FORMED THEREFROM
  申请人：ISIS PHARMACEUTICALS, INC.

  公开号：EP0739351A1

  公开（公告）日：1996-10-30