(3aS,6R,6aS)-6-(2,2-dimethyl-1,3-dioxolan-4-yl)-3a-(hydroxymethyl)-2,2-dimethyl-6,6a-dihydro-4H-furo[3,4-d][1,3]dioxol-4-ol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3aS,6R,6aS)-6-(2,2-dimethyl-1,3-dioxolan-4-yl)-3a-(hydroxymethyl)-2,2-dimethyl-6,6a-dihydro-4H-furo[3,4-d][1,3]dioxol-4-ol
• 化学式: C₁₃H₂₂O₇
• 分子量: 290.313
• InChiKey: SGJOYWAHFNJARE-FUTIGGTRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  86.6
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  lyxo-hexofuranose 在 聚合甲醛 、 碘 、 potassium carbonate 作用下， 反应 60.0h， 生成 (3aS,6R,6aS)-6-(2,2-dimethyl-1,3-dioxolan-4-yl)-3a-(hydroxymethyl)-2,2-dimethyl-6,6a-dihydro-4H-furo[3,4-d][1,3]dioxol-4-ol
  参考文献：
  名称：

  四乙酸铅介导的一锅氧化裂解和乙酰化反应：一种apio和同源apio嘧啶核苷及其抗癌活性的方法†

  摘要：

  已经描述了对apio和同源的apio嘧啶具有普遍适用性的有效且通用的策略。该方法显示了甲苯磺酸化，原位环化，一锅氧化裂解和Pb（OAc）4的乙酰化是关键步骤。该方法已经应用于D-核糖和D-甘露糖衍生物以实现apio和同源apio嘧啶核苷的不对称合成。

  DOI：

  10.1039/c5ra19080k

文献信息

• MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：EP2970353A2

  公开（公告）日：2016-01-20
• US20140274930A1
  申请人：——

  公开号：US20140274930A1

  公开（公告）日：2014-09-18
• US9890176B2
  申请人：——

  公开号：US9890176B2

  公开（公告）日：2018-02-13
• [EN] MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS<br/>[FR] DÉRIVÉS DU MANNOSE POUR LE TRAITEMENT D'INFECTIONS BACTÉRIENNES
  申请人：VERTEX PHARMA

  公开号：WO2014165107A2

  公开（公告）日：2014-10-09

  The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula (I) The invention also provides processes for making the compounds described herein. Furthermore, the present invention provides a composition comprising the compounds described herein, and a pharmaceutically acceptable carrier, adjuvant, or vehicle. The present invention also provides methods of treating or preventing bacteria infection in a subject, comprising administering to the subject an effective amount of the compound or the composition described herein.
• Lead tetraacetate mediated one pot oxidative cleavage and acetylation reaction: an approach to apio and homologated apio pyrimidine nucleosides and their anticancer activity
  作者：Amarendra Panda、Sehbanul Islam、Manas Kumar Santra、Shantanu Pal

  DOI：10.1039/c5ra19080k

  日期：——

  efficient and versatile strategy of general applicability towards apio and homologated apio pyrimidines has been delineated. The methodology shows tosylation followed by in situ cyclization and one pot oxidative cleavage and acetylation by Pb(OAc)4 as the key steps. The methodology has been applied to D-ribose and D-mannose derivatives to achieve asymmetric synthesis of apio and homologated apio pyrimidine

  已经描述了对apio和同源的apio嘧啶具有普遍适用性的有效且通用的策略。该方法显示了甲苯磺酸化，原位环化，一锅氧化裂解和Pb（OAc）4的乙酰化是关键步骤。该方法已经应用于D-核糖和D-甘露糖衍生物以实现apio和同源apio嘧啶核苷的不对称合成。