5-(3-methoxyphenyl)-3-(4-methoxyphenyl)-1,2,4-oxadiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(3-methoxyphenyl)-3-(4-methoxyphenyl)-1,2,4-oxadiazole
• 化学式: C₁₆H₁₄N₂O₃
• mdl: MFCD01152995
• 分子量: 282.299
• InChiKey: KCUBFRBGEDIMGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  57.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-甲氧基苯甲腈 在 羟胺 、 silver(I) acetate 、 palladium diacetate 、 三苯基膦 、 三氟乙酸 作用下， 以 乙醇 、 水 、 甲苯 为溶剂， 反应 1.08h， 生成 5-(3-methoxyphenyl)-3-(4-methoxyphenyl)-1,2,4-oxadiazole
  参考文献：
  名称：

  微波辐照下3-取代的1,2,4-恶二唑的钯催化银辅助C-5–H直接芳基化

  摘要：

  据报道，在钯催化剂和乙酸银存在下，3-取代的1,2,4-恶二唑与碘代芳烃的直接C-5-H芳基化反应。该方法提供了一种快速，可靠的方法来获得通用的3,5-二芳基-1,2,4-恶二唑衍生物，这是许多生物活性分子的常见部分。这种新方法的合成应用已在Ataluren和有效的RET抑制剂Yhhu251的简明合成中得到了证明。

  DOI：

  10.1002/adsc.201600913

文献信息

• Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such
  申请人：Southern Research Institute

  公开号：US10953017B2

  公开（公告）日：2021-03-23

  Methods for enhancing memory and/or learning and prevent neurodegeneration by administration of certain heterocyclic and aromatic compounds are described. The methods are particularly useful for treating patients suffering from a neurodegenerative disease such as (without limitation) Alzheimer's, Parkinsons's, Lou Gehrig's (ALS) disease or memory or learning impairment. A neuronal human cell-based assay that assess NF-kB gene up-regulation using a luciferase reporter is also provided that screens for compounds useful in methods for enhancing memory or learning.

  本文描述了通过服用某些杂环化合物和芳香族化合物来增强记忆和/或学习能力并防止神经变性的方法。这些方法特别适用于治疗神经退行性疾病患者，如（但不限于）阿尔茨海默氏症、帕金森氏症、卢盖里氏症（ALS）或记忆或学习障碍。此外，还提供了一种基于神经元人体细胞的检测方法，利用荧光素酶报告物评估 NF-kB 基因的上调，从而筛选出在增强记忆或学习能力的方法中有用的化合物。
• TREATMENT OF NEURODEGENERATIVE DISEASES, CAUSATION OF MEMORY ENHANCEMENT, AND ASSAY FOR SCREENING COMPOUNDS FOR SUCH
  申请人：Grimaldi Maurizio

  公开号：US20120245166A1

  公开（公告）日：2012-09-27

  Methods for enhancing memory and/or learning and prevent neurodegeneration by administration of certain heterocyclic and aromatic compounds are described. The methods are particularly useful for treating patients suffering from a neurodegenerative disease such as (without limitation) Alzheimer's, Parkinsons's, Lou Gehrig's (ALS) disease or memory or learning impairment. A neuronal human cell-based assay that assess NF-kB gene up-regulation using a luciferase reporter is also provided that screens for compounds useful in methods for enhancing memory or learning.
• US9095596B2
  申请人：——

  公开号：US9095596B2

  公开（公告）日：2015-08-04
• US9980969B2
  申请人：——

  公开号：US9980969B2

  公开（公告）日：2018-05-29
• [EN] TREATMENT OF NEURODEGENERATIVE DISEASES, CAUSATION OF MEMORY ENHANCEMENT, AND ASSAY FOR SCREENING COMPOUNDS FOR SUCH<br/>[FR] TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES, CAUSE D'AMÉLIORATION DE LA MÉMOIRE ET ANALYSE POUR ÉVALUER DES COMPOSÉS ASSOCIÉS
  申请人：SOUTHERN RES INST

  公开号：WO2011047129A1

  公开（公告）日：2011-04-21

  Methods for enhancing memory and/or learning and prevent neurodegeneration by administration of certain heterocyclic and aromatic compounds are described. The methods are particularly useful for treating patients suffering from a neurodegenerative disease such as (without limitation) Alzheimer's, Parkinsons's, and Lou Gehrig's (ALS) disease or memory or learning impairment. A neuronal human cell-based assay that assess NF-kB gene up-regulation using a luciferase reporter is also provided that screens for compounds useful in methods for enhancing memory or learning.