D-arabinitol 1-phosphate | 850728-02-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: D-arabinitol 1-phosphate
• 英文别名: [(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl] dihydrogen phosphate
• CAS: 850728-02-8
• 化学式: C₅H₁₃O₈P
• 分子量: 232.127
• InChiKey: VJDOAZKNBQCAGE-UOWFLXDJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  148
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  D-arabinitol 1-phosphate 在 D-arabinitol 1-phosphate dehydrogenase 、 nicotinamide adenine (NAD⁺) 作用下， 生成 5-O-膦酰-D-木酮糖
  参考文献：
  名称：

  Synthesis of arabinitol 1-phosphate and its use for characterization of arabinitol–phosphate dehydrogenase

  摘要：

  D-Arabinitol 1-phosphate (Ara-oll-P), a substrate for D-arabinitol-phosphate dehydrogenase (APDH), was chemically synthesized from D-arabinonic acid in five steps (O-acetylation, chlorination, reduction, phosphorylation, and de-O-acetylation). Ara-oll-P was used as a substrate for the characterization of APDH from Bacillus halodurans. APDH converts Ara-oll-P to xylulose 5-phosphate in the oxidative reaction; both NAD(+) and NADP(+) were accepted as co-factors. Kinetic parameters for the oxidative and reductive reactions are consistent with a ternary complex mechanism. (c) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2004.11.030
• 作为产物：
  描述：

  5-O-膦酰-D-木酮糖 在 D-arabinitol 1-phosphate dehydrogenase 、 nicotinamide adenine (NAD⁺) 作用下， 生成 D-arabinitol 1-phosphate
  参考文献：
  名称：

  Synthesis of arabinitol 1-phosphate and its use for characterization of arabinitol–phosphate dehydrogenase

  摘要：

  D-Arabinitol 1-phosphate (Ara-oll-P), a substrate for D-arabinitol-phosphate dehydrogenase (APDH), was chemically synthesized from D-arabinonic acid in five steps (O-acetylation, chlorination, reduction, phosphorylation, and de-O-acetylation). Ara-oll-P was used as a substrate for the characterization of APDH from Bacillus halodurans. APDH converts Ara-oll-P to xylulose 5-phosphate in the oxidative reaction; both NAD(+) and NADP(+) were accepted as co-factors. Kinetic parameters for the oxidative and reductive reactions are consistent with a ternary complex mechanism. (c) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2004.11.030

文献信息

• Synthesis of arabinitol 1-phosphate and its use for characterization of arabinitol–phosphate dehydrogenase
  作者：Nikolai V. Soroka、Anna A. Kulminskaya、Elena V. Eneyskaya、Konstantin A. Shabalin、Andrei V. Uffimtcev、Mira Povelainen、Andrei N. Miasnikov、Kirill N. Neustroev

  DOI：10.1016/j.carres.2004.11.030

  日期：2005.3

  D-Arabinitol 1-phosphate (Ara-oll-P), a substrate for D-arabinitol-phosphate dehydrogenase (APDH), was chemically synthesized from D-arabinonic acid in five steps (O-acetylation, chlorination, reduction, phosphorylation, and de-O-acetylation). Ara-oll-P was used as a substrate for the characterization of APDH from Bacillus halodurans. APDH converts Ara-oll-P to xylulose 5-phosphate in the oxidative reaction; both NAD(+) and NADP(+) were accepted as co-factors. Kinetic parameters for the oxidative and reductive reactions are consistent with a ternary complex mechanism. (c) 2004 Elsevier Ltd. All rights reserved.