2-半胱氨酸碘苯腈辛酸酯 | 57813-59-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-半胱氨酸碘苯腈辛酸酯
• 中文别名: 辛酸-2-巯基乙酯
• 英文名称: 2-mercaptooctanoic acid ethyl ester
• 英文别名: 2-mercaptoethyl caprylate；2-mercaptoethyl octanoate；2-sulfanylethyl octanoate
• CAS: 57813-59-9
• 化学式: C₁₀H₂₀O₂S
• 分子量: 204.334
• InChiKey: BHWWTWCFLZECFZ-UHFFFAOYSA-N

物化性质

• 沸点：
  272.5±23.0 °C(Predicted)
• 密度：
  0.967±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  13
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  27.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-半胱氨酸碘苯腈辛酸酯 在 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 9.0h， 生成 2-((2-hydroxyethyl)disulfanyl)ethyl octanoate
  参考文献：
  名称：

  一种脂质化合物、包含其的组合物及应用

  摘要：

  本发明涉及生物医药技术领域，具体公开了一种脂质化合物、包含其的组合物及应用。该脂质化合物具有式(I)或式(II)所示的结构。该脂质化合物在酸性条件下可电离成阳离子化合物，与带负电的药物活性成分通过静电相互作用结合，从而组装成载药脂质纳米颗粒，进行药物活性成分的递送。本发明所提供的脂质化合物结构简单，反应路径简单，产率高，构建得到的载药脂质纳米颗粒可用于制备核酸药物、基因疫苗、多肽或蛋白质药物、小分子药物，具备广泛的应用前景。

  公开号：

  CN114716355B
• 作为产物：
  描述：

  辛酰氯 、 2-巯基乙醇 在 三乙胺 作用下， 反应 0.25h， 生成 2-半胱氨酸碘苯腈辛酸酯
  参考文献：
  名称：

  一种脂质化合物、包含其的组合物及应用

  摘要：

  本发明涉及生物医药技术领域，具体公开了一种脂质化合物、包含其的组合物及应用。该脂质化合物具有式(I)或式(II)所示的结构。该脂质化合物在酸性条件下可电离成阳离子化合物，与带负电的药物活性成分通过静电相互作用结合，从而组装成载药脂质纳米颗粒，进行药物活性成分的递送。本发明所提供的脂质化合物结构简单，反应路径简单，产率高，构建得到的载药脂质纳米颗粒可用于制备核酸药物、基因疫苗、多肽或蛋白质药物、小分子药物，具备广泛的应用前景。

  公开号：

  CN114716355B

文献信息

• 6-Membered heterocyclic compound and use thereof
  申请人：Shoda Motoshi

  公开号：US20070060590A1

  公开（公告）日：2007-03-15

  A compound represented by the general formula (I) or a salt thereof: [T represents oxygen atom and the like; V represents CH 2 and the like; R O1 to R O4 represent hydrogen atom and the like; A represents a linear alkylene group or linear alkenylene group having 2 to 8 carbon atoms and the like; D represents carboxyl group and the like; X represents ethylene group, trimethylene group and the like; E represents —CH(OH)— group and the like; and W represent —U 1 —(R W1 )(R W2 )—U 2 —U 3 group (U 1 represents a single bond, an alkylene group having 1 to 4 carbon atoms and the like; R W1 and R W2 represent hydrogen atom and the like; U 2 represents a single bond, an alkylene group having 1 to 4 carbon atoms and the like; and U 3 represent an alkyl group having 1 to 8 carbon atoms and the like), or a residue of a carbon ring or heterocyclic compound], which can be utilized as an active ingredient of medicaments effective for prophylactic and/or therapeutic treatment of skeletal diseases such as osteoporosis and fracture, glaucoma, ulcerative colitis and the like.

  由通用公式(I)表示的化合物或其盐： [T代表氧原子等；V代表CH2等；RO1至RO4代表氢原子等；A代表具有2至8个碳原子的线型亚烷基或线型亚烯基等；D代表羧基等；X代表亚乙基、亚丙基等；E代表—CH(OH)—基团等；W代表—U1—(RW1)(RW2)—U2—U3基团（U1代表单键、具有1至4个碳原子的亚烷基等；RW1和RW2代表氢原子等；U2代表单键、具有1至4个碳原子的亚烷基等；U3代表具有1至8个碳原子的烷基等），或碳环或杂环化合物的残基]，其可作为预防性和/或治疗性药物的有效成分，用于治疗骨骼疾病如骨质疏松症和骨折、青光眼、溃疡性结肠炎等。
• Polycarboxylic acid copolymer, production method and use thereof
  申请人：——

  公开号：US20020193547A1

  公开（公告）日：2002-12-19

  It is an object of the present invention to provide a polycarboxylic acid copolymer which improves the water reducing capacity and workability of cement compositions and the like and making them easier to handle when the fluidity and water reducing capacity are at the same levels, a method of producing the copolymer, and a cement additive and a cement composition comprising the copolymer. The present invention is further to provide a polycarboxylic acid copolymer and a cement additive which are capable of improving the strength and durability of hardening products of cement compositions, hence can advantageously be used in ultrahigh strength concrete. The present invention is still further to provide a method of producing polycarboxylic acid copolymers having high water reducing capacity, reducing the viscosity of cement compositions and improving the workability in applying cement. The present invention is directed to a polycarboxylic acid copolymer which is obtained by copolymerization of monomer components comprising a polyalkyleneimine unsaturated monomer (A1) and an unsaturated carboxylic acid monomer (B).

  本发明的目的是提供一种聚羧酸共聚物，该共聚物可以提高水减量和可操作性，并使其更易于处理，当流动性和水减量相同时，制备该共聚物的方法以及包括该共聚物的水泥添加剂和水泥组合物。本发明还提供了一种聚羧酸共聚物和水泥添加剂，它们能够提高水泥组合物的硬化产品的强度和耐久性，因此可以有利地用于超高强度混凝土。本发明还提供了一种制备具有高水减量能力的聚羧酸共聚物的方法，该方法可以减少水泥组合物的粘度并改善应用水泥的可操作性。本发明涉及一种聚羧酸共聚物，该共聚物通过共聚合包括聚烷基亚胺不饱和单体（A1）和不饱和羧酸单体（B）的单体组分而得到。
• EMULSION COMPOSITION FOR VIBRATION DAMPING MATERIALS
  申请人：NIPPON SHOKUBAI CO., LTD.

  公开号：US20160035340A1

  公开（公告）日：2016-02-04

  The present invention aims to provide a composition for vibration damping materials which provides excellent vibration damping property. The present invention relates to an emulsion composition for vibration damping materials including: a vibration damping modifier including a compound that has 7 or more carbon atoms, a boiling point of 190° C. or higher, and at least two ether groups or at least two ester groups in the molecule; and a polymer emulsion.

  本发明旨在提供一种用于振动减震材料的组合物，该组合物具有优异的振动减震性能。本发明涉及一种用于振动减震材料的乳液组合物，包括：振动减震改性剂，包括具有7个或更多碳原子，沸点高于190°C，并且分子中至少有两个醚基或至少有两个酯基的化合物；以及聚合物乳液。
• Improvements in or relating to heat stabilizer compositions and to halogen-containing polymers or resins containing the heat stabilizer compositions
  申请人：M & T CHEMICALS, INC.

  公开号：EP0013839A1

  公开（公告）日：1980-08-06

  The combination of one or more conventional antimony - or bismuth-containing heat stabilizers with certain aromatic esters or aryloxides containing boron, phosphorus, silicon, antimony, tin or zinc interacts synergistically to provide an unexpectedly high level of heat stability to halogen-containing polymers or resins such as polyvinyl chloride (PVC). In addition the aromatic ester or aryloxide inhibits spontaneous degradation of the stabilizing component in the presence of heat and/or light.

  将一种或多种传统的含锑或铋的热稳定剂与某些含硼、磷、硅、锑、锡或锌的芳香族酯或芳基氧化物结合使用，可产生协同作用，为聚氯乙烯（PVC）等含卤聚合物或树脂提供意想不到的高热稳定性。此外，芳香族酯或芳基氧化物还能抑制稳定组分在热和/或光的作用下自发降解。
• Process for the production of heat resistant methacrylic resin
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0178115A2

  公开（公告）日：1986-04-16

  Improved process for the production of a methacrylic polymer having excellent heat resistance, which comprises radical- polymerizing a monomer or monomer mixture consisting of 80 to 100% by weight of methyl methacrylate and 0 to 20% by weight of a copolymerizable vinyl monomer in the presence of a polymerization initiator and at least one specific chain transfer agent which is (A) a 2-mercaptoethyl alkanecarboxylate of the formula: wherein R is an alkyl group having from 4 to 12 carbon atoms, or (B) an alkyl 3-mercaptopropionate of the formula: wherein R is an alkyl group having from 4 to 18 carbon atoms. The methacrylic resin prepared by this invention has excellent heat resistance and can provide formed products having excellent heat resistance (high heat distoration temperature) without an increase in monomer content during the processing thereof.

  生产具有优异耐热性的甲基丙烯酸聚合物的改进工艺，该工艺包括在聚合引发剂和至少一种特定链转移剂存在的情况下，对由重量百分比为 80%至 100%的甲基丙烯酸甲酯和重量百分比为 0%至 20%的可共聚乙烯基单体组成的单体或单体混合物进行自由基聚合，该单体或单体混合物具有以下特性 (A) 式中的 2-巯乙基烷基羧酸酯： 其中 R 是具有 4 至 12 个碳原子的烷基，或 (B) 式中的 3-巯基丙酸烷基酯： 其中 R 是具有 4 至 18 个碳原子的烷基。本发明制备的甲基丙烯酸树脂具有优异的耐热性，在加工过程中无需增加单体含量，即可提供具有优异耐热性（高热分解温度）的成型产品。