(1S,3R)-3-amino-1,3-diphenyl-propan-1-ol | 13286-60-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (1S,3R)-3-amino-1,3-diphenyl-propan-1-ol
• 英文别名: (1S,3R)-3-amino-1,3-diphenylpropan-1-ol
• CAS: 13286-60-7；1263078-04-1
• 化学式: C₁₅H₁₇NO
• 分子量: 227.306
• InChiKey: HQFWJAGMDNUMAK-CABCVRRESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (1R,3S)-3-amino-1,3-diphenylpropan-1-ol 在 ammonium salt of the (1S)-3-endo-bromo-2-oxo-bornane-8-sulfonic acid 作用下， 生成 (1S,3R)-3-amino-1,3-diphenyl-propan-1-ol
  参考文献：
  名称：

  Pulmonary cryptococcosis and Capillaria aerophila infection in an FIV-positive cat

  摘要：

  A 12‐year‐old, FIV‐positive, domestic longhair cat was presented with a history of sneezing and coughing during the previous seven months. On thoracic radiographs, a prominent bronchial pattern and three focal, opacified nodules were seen. Cytology of bronchoalveolar lavage fluid demonstrated spherical, capsulate, narrow‐necked, budding yeasts within macrophages. Culture of the fluid yielded a heavy growth of Cryptococcus neoformans var neoformans. The serum latex cryptococcal antigen agglutination test titre was 158. The cat was treated with itraconazole and the cough resolved over a 5‐month period but then recurred. Repeat thoracic radiographs showed resolution of the pulmonary nodules but a persistent bronchial pattern. Adult nematodes and ova with morphology characteristic of Capillaria aerophila were seen in bronchoalveolar lavage fluid and no yeasts were cultured from the fluid. The cryptococcal titre was zero. The lungworm infection was treated successfully with abamectin and the cough resolved. Immunosuppression related to FIV infection may have predisposed this cat to sequential respiratory tract infections.

  DOI：

  10.1111/j.1751-0813.2000.tb10581.x

文献信息

• Asymmetric reduction of racemic 2-isoxazolines
  作者：Masashi Tokizane、Kaori Sato、Tetsuo Ohta、Yoshihiko Ito

  DOI：10.1016/j.tetasy.2008.11.005

  日期：2008.11

  The kinetic resolution of racemic 2-isoxazolines was carried out by asymmetric reduction using borane with 1,2-amino alcohols as a chiral Source. Using excess BH3-THF in the presence of (-)-norephedrine, optically active 1,3-amino alcohol derivatives were obtained with good ee but in lower yield, while the optically active substrates 2-isoxazolines were recovered with modest ee. The asymmetric reduction using 2.0 equiv of BH3-SMe2 was investigated as an alternative strategy for the synthesis of optically active products. After reduction, treatment of the resulting Mixture with Et3N was successful in providing optically active isoxazolidine derivatives in good yields and with good ee. The choice of chiral source was also shown to have a significant effect. In particular, the use of (S)-alpha,alpha-diphenyl-2-pyrrolidinemethanol reversed the enantioselectivity of the recovered Substrates. (C) 2008 Elsevier Ltd. All rights reserved.
• Pulmonary cryptococcosis and Capillaria aerophila infection in an FIV-positive cat
  作者：VR BARRS、P. MARTIN、RG NICOLL、JA BEATTY、R. MALIK

  DOI：10.1111/j.1751-0813.2000.tb10581.x

  日期：2000.3

  A 12‐year‐old, FIV‐positive, domestic longhair cat was presented with a history of sneezing and coughing during the previous seven months. On thoracic radiographs, a prominent bronchial pattern and three focal, opacified nodules were seen. Cytology of bronchoalveolar lavage fluid demonstrated spherical, capsulate, narrow‐necked, budding yeasts within macrophages. Culture of the fluid yielded a heavy growth of Cryptococcus neoformans var neoformans. The serum latex cryptococcal antigen agglutination test titre was 158. The cat was treated with itraconazole and the cough resolved over a 5‐month period but then recurred. Repeat thoracic radiographs showed resolution of the pulmonary nodules but a persistent bronchial pattern. Adult nematodes and ova with morphology characteristic of Capillaria aerophila were seen in bronchoalveolar lavage fluid and no yeasts were cultured from the fluid. The cryptococcal titre was zero. The lungworm infection was treated successfully with abamectin and the cough resolved. Immunosuppression related to FIV infection may have predisposed this cat to sequential respiratory tract infections.