Phenyl L-Z-Isoleucinamide | 134015-93-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Phenyl L-Z-Isoleucinamide
• 英文别名: benzyl N-[(2S,3S)-1-anilino-3-methyl-1-oxopentan-2-yl]carbamate
• CAS: 134015-93-3
• 化学式: C₂₀H₂₄N₂O₃
• 分子量: 340.422
• InChiKey: OYDMDVAWACLEQO-YJBOKZPZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Phenyl L-Z-Isoleucinamide 在 氢溴酸 、 溶剂黄146 、 sodium hydroxide 作用下， 以 水 为溶剂， 生成 Phenyl L-Isoleucinamide
  参考文献：
  名称：

  Enantioselective nickel-catalyzed conjugate addition of dialkylzinc to chalcones using chiral α-amino amides

  摘要：

  A series of alpha-amino amides derived from natural amino acids (alanine, valine, phenylalanine, isoleucine, and phenylglycine) have been synthesized and fully characterized. Their Ni(II) complexes prepared from Ni(acac)(2) catalyze the enantioselective conjugate addition of diethylzinc to chalcones in high yields and in good enantioselectivities (up to 84%). The side chain of the amino acid and the substituents in the amide nitrogen govern the enantioselectivity of the catalytic process. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.09.120
• 作为产物：
  描述：

  N-(苯基甲氧基羰基)-L-异亮氨酸 2,5-二氧代-1-吡咯烷基酯 、 苯胺 以 四氢呋喃 为溶剂， 反应 12.0h， 生成 Phenyl L-Z-Isoleucinamide
  参考文献：
  名称：

  Enantioselective nickel-catalyzed conjugate addition of dialkylzinc to chalcones using chiral α-amino amides

  摘要：

  A series of alpha-amino amides derived from natural amino acids (alanine, valine, phenylalanine, isoleucine, and phenylglycine) have been synthesized and fully characterized. Their Ni(II) complexes prepared from Ni(acac)(2) catalyze the enantioselective conjugate addition of diethylzinc to chalcones in high yields and in good enantioselectivities (up to 84%). The side chain of the amino acid and the substituents in the amide nitrogen govern the enantioselectivity of the catalytic process. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.09.120

文献信息

• Enantioselective nickel-catalyzed conjugate addition of dialkylzinc to chalcones using chiral α-amino amides
  作者：Jorge Escorihuela、M. Isabel Burguete、Santiago V. Luis

  DOI：10.1016/j.tetlet.2008.09.120

  日期：2008.11

  A series of alpha-amino amides derived from natural amino acids (alanine, valine, phenylalanine, isoleucine, and phenylglycine) have been synthesized and fully characterized. Their Ni(II) complexes prepared from Ni(acac)(2) catalyze the enantioselective conjugate addition of diethylzinc to chalcones in high yields and in good enantioselectivities (up to 84%). The side chain of the amino acid and the substituents in the amide nitrogen govern the enantioselectivity of the catalytic process. (c) 2008 Elsevier Ltd. All rights reserved.