3-butyl-N-[3-(dimethylamino)propyl]-3-phenylheptanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-butyl-N-[3-(dimethylamino)propyl]-3-phenylheptanamide
• 化学式: C₂₂H₃₈N₂O
• 分子量: 346.557
• InChiKey: LVCPGPKABLZSOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  25
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-壬酮 在 ammonium acetate 、 copper(l) cyanide 、 1-羟基苯并三唑 、 溶剂黄146 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 potassium hydroxide 作用下， 以 四氢呋喃 、 乙二醇 、 N,N-二甲基甲酰胺 、 苯 为溶剂， 生成 3-butyl-N-[3-(dimethylamino)propyl]-3-phenylheptanamide
  参考文献：
  名称：

  Back matter

  摘要：

  DOI：

  10.1039/c3mb90040a

文献信息

• COMPOSITIONS AND METHODS FOR MEMBRANE PROTEIN DETERGENT STABILITY SCREEN
  申请人：Wiener Michael C.

  公开号：US20120108463A1

  公开（公告）日：2012-05-03

  The invention provides methods to assess protein stability and to obtain sizing information. In one aspect, the screen comprises a 94 detergent panel and a series of MWCO filtered microplates. A protein of interest is bound to an affinity matrix and aliquoted into a 96-well microplate. Wells containing the immobilized protein are washed in the new detergent and then eluted in the new detergent into a collection plate. Protein not stable in the new detergent is precipitated on the resin and not present in the elutions. Half of the elution is passed through a high (i.e., 300 kDa) MWCO microplate and the other half through a low (i.e., 100 kDa) MWCO microplate. Elutions from the microplates are spotted on a nitrocellulose membrane, visualized by Western analysis (or by some other method), and quantified. The high MWCO provides stability readout and the ratio of low/high kDa provides sizing information.
• US9606126B2
  申请人：——

  公开号：US9606126B2

  公开（公告）日：2017-03-28
• Back matter
  作者：Chae, Pil Seok、Laible, Philip D.、Gellman, Samuel H.

  DOI：10.1039/c3mb90040a

  日期：——