(2S,3R,5R,7R)-1-[(4-methoxyphenyl)methoxy]-2-methyl-7-phenylmethoxydec-9-ene-3,5-diol | 1416813-07-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2S,3R,5R,7R)-1-[(4-methoxyphenyl)methoxy]-2-methyl-7-phenylmethoxydec-9-ene-3,5-diol
• CAS: 1416813-07-4
• 化学式: C₂₆H₃₆O₅
• 分子量: 428.569
• InChiKey: HBODFMYIBINALD-XOEVLYMDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  31
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  68.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (R)-1-((4-methoxybenzyl)oxy)hex-5-en-3-ol 在 sodium hydride 、 碳酸氢钠 、 戴斯-马丁氧化剂 、 三乙胺 、 (+)-二异松蒎基氯硼烷 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 、 mineral oil 为溶剂， 反应 147.33h， 生成 (2S,3R,5R,7R)-1-[(4-methoxyphenyl)methoxy]-2-methyl-7-phenylmethoxydec-9-ene-3,5-diol
  参考文献：
  名称：

  Stereoselective Synthesis of 1,3-anti Diols by an Ipc-Mediated Domino Aldol-Coupling/Reduction Sequence

  摘要：

  A novel domino process for 1,3-anti diol synthesis by the union of a methyl ketone with an aldehyde is described. The operationally simple procedure is based on an Ipc-boron-aldol coupling and subsequent Ipc-mediated reduction of the intermediate beta-hydroxy-ketone. The sequence proceeds with excellent anti-selectivities and enables the rapid construction of complex polyketide fragments.

  DOI：

  10.1021/ol3033303

文献信息

• Stereoselective Synthesis of 1,3-<i>anti</i> Diols by an Ipc-Mediated Domino Aldol-Coupling/Reduction Sequence
  作者：Michael Dieckmann、Dirk Menche

  DOI：10.1021/ol3033303

  日期：2013.1.4

  A novel domino process for 1,3-anti diol synthesis by the union of a methyl ketone with an aldehyde is described. The operationally simple procedure is based on an Ipc-boron-aldol coupling and subsequent Ipc-mediated reduction of the intermediate beta-hydroxy-ketone. The sequence proceeds with excellent anti-selectivities and enables the rapid construction of complex polyketide fragments.