5-isopropyl-γ-carboline | 1028068-01-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-isopropyl-γ-carboline
• 英文别名: 5-Propan-2-ylpyrido[4,3-b]indole
• CAS: 1028068-01-0
• 化学式: C₁₄H₁₄N₂
• 分子量: 210.279
• InChiKey: KEGYFWATWZUTSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-isopropyl-γ-carboline 、 苯甲酰氯 在 aluminum (III) chloride 、 sodium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 3.0h， 以67%的产率得到8-benzoyl-5-isopropyl-γ-carboline
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of novel γ-carboline ketones as anticancer agents

  摘要：

  A series of novel gamma-carboline ketones were designed, synthesized and evaluated for their cytotoxic activity in vitro against six human cancer cell lines (A549, SGC, HCT116, MCF-7, K562 and K562R). Biological evaluation revealed that almost all of the new compounds displayed moderate to potent cytotoxic activities against the tested cells. Among them, seven of the fourteen new compounds show more potent cytotoxic activities against K562R cell line than that of the positive control, taxol. Primary mechanism research on the most potent compound 6f indicated that it was a potent tubulin polymerization inhibitor, with IC(50) value of 4.3 mu M, equivalent to that of CA-4, and arresting cell cycle in G(2)/M phase. (c) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.01.057
• 作为产物：
  描述：

  2-碘代丙烷 、 5H-吡啶并[4,3-b]吲哚 在 sodium hydride 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 以55.7%的产率得到5-isopropyl-γ-carboline
  参考文献：
  名称：

  γ-Carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity

  摘要：

  Based on anti-viral screening of our heteroaromatics derived from thalidomide, the gamma-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-gamma-carboline), with the EC50 of 0.26 mu M. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.01.052

文献信息

• [EN] COMPOSITION OF MATTER FOR USE ORGANIC LIGHT-EMITTING DIODES<br/>[FR] COMPOSITION DE MATIÈRE DESTINÉE À ÊTRE UTILISÉE DANS DES DIODES ÉLECTROLUMINESCENTES ORGANIQUES
  申请人：KYULUX INC

  公开号：WO2019191454A1

  公开（公告）日：2019-10-03

  The present disclosure relates to compounds of Formula (I), (II), or (III) as compounds capable of emitting delayed fluorescence, and uses of the compounds in organic light-emitting diodes.

  本公开涉及化合物的公式(I)、(II)或(III)作为能够发射延迟荧光的化合物，以及在有机发光二极管中使用这些化合物的用途。
• COMPOSITION OF MATTER FOR USE IN ORGANIC LIGHT-EMITTING DIODES
  申请人：Kyulux, Inc.

  公开号：US20190233412A1

  公开（公告）日：2019-08-01

  The present disclosure relates to compounds capable of emitting delayed fluorescence and uses of these compounds in organic light-emitting diodes.

  本公开涉及能够发射延迟荧光的化合物以及这些化合物在有机发光二极管中的应用。
• Platinum complexes and devices
  申请人：Arizona Board of Regents on behalf of Arizona State University

  公开号：US10566553B2

  公开（公告）日：2020-02-18

  Platinum compounds of Formulas I and II useful in a variety of devices, such as, for example organic-light emitting diodes (OLEDs).

  式 I 和式 II 的铂化合物可用于各种设备，例如有机发光二极管（OLED）。
• Composition of matter for use in organic light-emitting diodes
  申请人：Kyulux, Inc.

  公开号：US10644249B2

  公开（公告）日：2020-05-05

  The present disclosure relates to compounds of Formula (I), (II), (III), (IV), or (V): as compounds capable of emitting delayed fluorescence, and uses of the compounds in organic light-emitting diodes.

  本公开涉及式 (I)、(II)、(III)、(IV) 或 (V) 的化合物： 作为能够发出延迟荧光的化合物，以及这些化合物在有机发光二极管中的用途。
• PLATINUM COMPLEXES AND DEVICES
  申请人：Arizona Board of Regents Acting for and on Behalf of Arizona State University

  公开号：US20170012224A1

  公开（公告）日：2017-01-12

  Platinum compounds of Formulas I and II useful in a variety of devices, such as, for example organic-light emitting diodes (OLEDs).