| 1252027-36-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1252027-36-3
• 化学式: C₂₆H₂₇N₃O₄S
• 分子量: 477.584
• InChiKey: OOPBQORWNNDRDF-ZFXZZAOISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.35
• 重原子数：
  34.0
• 可旋转键数：
  10.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  96.68
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  苯基硫三甲基硅烷 、 1,6-anhydro-2-azido-3,4-di-O-benzyl-2-deoxy-D-glucopyranose 在 zinc(II) iodide 作用下， 以 二氯甲烷 为溶剂， 生成 phenyl 2-azido-3,4-di-O-benzyl-2-deoxy-1-thio-β-D-glucopyranoside 、
  参考文献：
  名称：

  Synthesis of glycosaminoglycan oligosaccharides. Part 4: Synthesis of aza-l-iduronic acid-containing analogs of heparan sulfate oligosaccharides as heparanase inhibitors

  摘要：

  The synthesis of three azasugar-containing analogs of the disaccharide units of heparan sulfate, which are potential inhibitors of the enzyme heparanase, is reported. Synthetic routes were developed for the preparation of L-ido-nojirimycin type glycosyl acceptors with O-4 free. Glycosylation of these acceptors with an O-6 functionalized 2-azido-2-deoxy-n-glucose thioglycoside donor afforded the a-linked disaccharides in good yields. The advantages of using the 4-nitrobenzenesulfonyl group for the protection of the ring nitrogen of azasugars were demonstrated. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.07.055