2-amino-4-(4-aminophenyl)imidazole dihydrochloride | 65146-52-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-amino-4-(4-aminophenyl)imidazole dihydrochloride
• 英文别名: 4-(4-amino-phenyl)-1(3)H-imidazol-2-ylamine; dihydrochloride；5-(4-aminophenyl)-1H-imidazol-2-amine;hydrochloride
• CAS: 65146-52-3
• 化学式: C₉H₁₀N₄*2ClH
• 分子量: 247.127
• InChiKey: QRMGFEDMRSBDNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.66
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.7
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  异氰酸丙酯 、 2-amino-4-(4-aminophenyl)imidazole dihydrochloride 在 sodium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 4.0h， 以25%的产率得到2-amino-4-(4-aminophenyl)-1H-1,3-diazol-1-yl-propylaminomethione
  参考文献：
  名称：

  A facile and new approach to synthesize 2-amino-4-(4-amoinophenyl)-1H-1,3-diazol-1-yl-alkylaminomethanethiones

  摘要：

  An "intellectual connection" approach to design a facile and new synthesis of suitably substituted 2-aminoimidazole-based precursors of expected antiasthmatic agents through a benzidine type of rearrangement of 2-phenylazoimidazole and subsequent coupling of the product thus obtained with alkylisothiocyanates involving a degenerative operation, thereby improving the time frame of the overall synthetic sequence, is reported. The alkylisothiocyanates required in this synthetic sequence are prepared using a best combination of reported methods. The compounds reported here can be used to produce derivatives of other biological agents.

  DOI：

  10.1007/s00044-007-9003-1
• 作为产物：
  描述：

  N-(imidazol-2-ylideneamino)aniline 在 tin(ll) chloride 作用下， 以 盐酸 为溶剂， 反应 1.5h， 以85%的产率得到2-amino-4-(4-aminophenyl)imidazole dihydrochloride
  参考文献：
  名称：

  A facile and new approach to synthesize 2-amino-4-(4-amoinophenyl)-1H-1,3-diazol-1-yl-alkylaminomethanethiones

  摘要：

  An "intellectual connection" approach to design a facile and new synthesis of suitably substituted 2-aminoimidazole-based precursors of expected antiasthmatic agents through a benzidine type of rearrangement of 2-phenylazoimidazole and subsequent coupling of the product thus obtained with alkylisothiocyanates involving a degenerative operation, thereby improving the time frame of the overall synthetic sequence, is reported. The alkylisothiocyanates required in this synthetic sequence are prepared using a best combination of reported methods. The compounds reported here can be used to produce derivatives of other biological agents.

  DOI：

  10.1007/s00044-007-9003-1

文献信息

• [EN] INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE-PHENYL DERIVATIVES<br/>[FR] INHIBITION DE BIOFILMS BACTÉRIENS PAR DES DÉRIVÉS D'IMIDAZOLE-PHÉNYLE
  申请人：UNIV NORTH CAROLINA STATE

  公开号：WO2009123753A1

  公开（公告）日：2009-10-08

  Disclosure is provided for imidazole-phenyl derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.

  本文提供了一种防止、去除和/或抑制生物膜形成的咪唑-苯衍生物化合物的披露，以及包含这些化合物的组合物、包含这些化合物的设备和使用这些化合物的方法。
• INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE-PHENYL DERIVATIVES
  申请人：Melander Christian

  公开号：US20090270475A1

  公开（公告）日：2009-10-29

  Disclosure is provided for imidazole-phenyl derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.

  本文提供了一种咪唑-苯衍生物化合物的披露，它们可以预防、去除和/或抑制生物膜的形成，包括这些化合物的组合物、装置和使用它们的方法。
• New, Facile Approach to Biologically Significant and Functionalizable Heterobiaryls
  作者：Raman K. Verma、Monika Aggarwal、Manisha Bansal、Inder Preet Kaur

  DOI：10.1080/00397910701354756

  日期：2007.6
• US9005643B2
  申请人：——

  公开号：US9005643B2

  公开（公告）日：2015-04-14
• US9975857B2
  申请人：——

  公开号：US9975857B2

  公开（公告）日：2018-05-22