2-Allylsulfamoyl-pent-4-enoic acid isopropyl ester | 303153-16-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Allylsulfamoyl-pent-4-enoic acid isopropyl ester
• 英文别名: Propan-2-yl 2-(prop-2-enylsulfamoyl)pent-4-enoate
• CAS: 303153-16-4
• 化学式: C₁₁H₁₉NO₄S
• 分子量: 261.342
• InChiKey: JNACYZLVUFPWMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  80.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-Allylsulfamoyl-pent-4-enoic acid isopropyl ester 在 polystyrene bound Grubbs ruthenium catalyst 1-己烯 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 0.5h， 以95%的产率得到Propan-2-yl 1,1-dioxo-2,3,6,7-tetrahydrothiazepine-7-carboxylate
  参考文献：
  名称：

  Ring-closing metathesis to a divergent endocyclic sulfonamide template

  摘要：

  The efficient synthesis of a novel endocyclic sulfonamide template via a ring-closing metathesis methodology is reported. A solid-supported variant of the Grubbs catalyst is shown to be effective and the suitability of the template for both combinatorial derivatization and potential incorporation into peptidomimetics is demonstrated. (C) 2000 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(00)01167-9
• 作为产物：
  描述：

  isopropyl (chlorosulfonyl)acetate 在 4-二甲氨基吡啶 、 potassium carbonate 、 三乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-Allylsulfamoyl-pent-4-enoic acid isopropyl ester
  参考文献：
  名称：

  Ring-closing metathesis to a divergent endocyclic sulfonamide template

  摘要：

  The efficient synthesis of a novel endocyclic sulfonamide template via a ring-closing metathesis methodology is reported. A solid-supported variant of the Grubbs catalyst is shown to be effective and the suitability of the template for both combinatorial derivatization and potential incorporation into peptidomimetics is demonstrated. (C) 2000 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(00)01167-9

文献信息

• Ring-closing metathesis to a divergent endocyclic sulfonamide template
  作者：Daniel D Long、Andreas P Termin

  DOI：10.1016/s0040-4039(00)01167-9

  日期：2000.8

  The efficient synthesis of a novel endocyclic sulfonamide template via a ring-closing metathesis methodology is reported. A solid-supported variant of the Grubbs catalyst is shown to be effective and the suitability of the template for both combinatorial derivatization and potential incorporation into peptidomimetics is demonstrated. (C) 2000 Published by Elsevier Science Ltd.