(6E,8E)-Deca-6,8-dienoic acid | 111876-08-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (6E,8E)-Deca-6,8-dienoic acid
• 英文别名: 6E,8E-decadienoic acid
• CAS: 111876-08-5
• 化学式: C₁₀H₁₆O₂
• 分子量: 168.236
• InChiKey: KMPQVMWMDOWSLS-MQQKCMAXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (6E,8E)-Deca-6,8-dienoic acid 在 正丁基锂 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 13.0h， 生成 methyl (5E,7E)-2-nona-5,7-dienyl-1H-indole-1-carboxylate
  参考文献：
  名称：

  Directed synthesis of 2-spiroindolines from indole derivatives by formic acid-induced N-acyliminium ion-conjugated diene spirocyclization

  摘要：

  Synthesis of 2-spiroindolines from 2-substituted indole derivatives via acid-induced N-acyliminium ionconjugated diene spirocyclization was demonstrated. This methodology can be used to direct transformations of 2-substituted indole moieties into 3-nonsubstituted-2-spiroindoline skeletons. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.12.130
• 作为产物：
  描述：

  (2-[(N-benzylprolyl)amino]benzophenone) 在 sodium chlorite 、 sodium dihydrogenphosphate dihydrate 作用下， 以 水 、 叔丁醇 为溶剂， 反应 0.17h， 生成 (6E,8E)-Deca-6,8-dienoic acid
  参考文献：
  名称：

  Directed synthesis of 2-spiroindolines from indole derivatives by formic acid-induced N-acyliminium ion-conjugated diene spirocyclization

  摘要：

  Synthesis of 2-spiroindolines from 2-substituted indole derivatives via acid-induced N-acyliminium ionconjugated diene spirocyclization was demonstrated. This methodology can be used to direct transformations of 2-substituted indole moieties into 3-nonsubstituted-2-spiroindoline skeletons. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.12.130

文献信息

• The intramolecular Diels–Alder reaction with allenic ester dienophiles
  作者：Helen M. Saxton、James K. Sutherland、Christopher Whaley

  DOI：10.1039/c39870001449

  日期：——

  Methyl (E,E)-dodeca-2,3,8,10-tetraenoate and (E,E)-undeca-2,3,7,9-tetraenoate have been prepared and shown to undergo intramolecular Diels-Alder reactions, the latter spontaneously at ambient temperature.

  已经制备了（E，E）-dodeca-2,3,8,10-丁烯酸甲酯和（E，E）-undeca-2,3,7,9-丁烯酸甲酯并显示出它们会发生分子内Diels-Alder反应，后者在环境温度下自然发生。
• PHARMACEUTICAL COMPOSITION AND METHODS
  申请人：Lipocine Inc.

  公开号：EP3185873A1

  公开（公告）日：2017-07-05
• (17-ß)-3-OXOANDROST-4-EN-17-YL UNDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
  申请人：Lipocine Inc.

  公开号：US20160193225A1

  公开（公告）日：2016-07-07

  Disclosed herein are compositions having a lipophilic active agent and methods of their use.
• (17-ß)-3-Oxoandrost-4-En-17-Yl Undecanoate Compositions and Methods of Their Preparation and Use
  申请人：Lipocine Inc.

  公开号：US20180104257A1

  公开（公告）日：2018-04-19

  Disclosed herein are compositions having a lipophilic active agent and methods of their use.
• [EN] (17-β)-3-OXOANDROST-4-EN-17-YL UNDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE<br/>[FR] COMPOSITIONS D'UNDÉCANOATE DE (17-Β)-3-OXO-ANDROST-4-ÉN -17-YLE, ET PROCÉDÉS DE PRÉPARATION ET D'UTILISATION DE CEUX-CI
  申请人：LIPOCINE INC

  公开号：WO2016033611A1

  公开（公告）日：2016-03-03

  Disclosed herein are compositions having a lipophilic active agent and methods of their use. This invention further discloses substantially pure (17-beta)-3-0xoandrost-4-en-17-yl undecanoate includes (17-beta)-3-0xoandrost-4-en-17-yl undecanoate substantially free of synthetic impurities, decomposition impurities or both.