4-fluorobenzyl 2-(5-fluoro-3-((1-(4-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetate | 1558049-81-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-fluorobenzyl 2-(5-fluoro-3-((1-(4-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetate
• CAS: 1558049-81-2
• 化学式: C₃₀H₂₄F₃N₃O₃
• 分子量: 531.534
• InChiKey: KQCHYCGEUSKNJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.31
• 重原子数：
  39.0
• 可旋转键数：
  8.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  66.12
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  4-fluorobenzyl 2-(5-fluoro-3-((1-(4-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetate 在 sodium hydroxide 、 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 16.0h， 以21.2%的产率得到(3-{[1-(4-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]methyl}-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid
  参考文献：
  名称：

  Discovery of Isoquinolinone Indole Acetic Acids as Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases

  摘要：

  Previously we reported the discovery of CRA-898 (1), a diazine indole acetic acid containing CRTH2 antagonist. This compound had good in vitro and in vivo potency, low rates of metabolism, moderate permeability, and good oral bioavailability in rodents. However, it showed low oral exposure in nonrodent safety species (dogs and monkeys). In the current paper, we wish to report our efforts to understand and improve the poor PK in nonrodents and development of a new isoquinolinone subseries that led to identification of a new development candidate, CRA-680 (44). This compound was efficacious in both a house dust mouse model of allergic lung inflammation (40 mg/kg qd) as well as a guinea pig allergen challenge model of lung inflammation (20 mg/kg bid).

  DOI：

  10.1021/jm401509e
• 作为产物：
  描述：

  2-(5-氟-2-甲基-1H-吲哚-1-基)乙酸甲酯 在 三乙基硅烷 、 aluminum (III) chloride 、 potassium carbonate 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 41.0h， 生成 4-fluorobenzyl 2-(5-fluoro-3-((1-(4-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetate
  参考文献：
  名称：

  Discovery of Isoquinolinone Indole Acetic Acids as Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases

  摘要：

  Previously we reported the discovery of CRA-898 (1), a diazine indole acetic acid containing CRTH2 antagonist. This compound had good in vitro and in vivo potency, low rates of metabolism, moderate permeability, and good oral bioavailability in rodents. However, it showed low oral exposure in nonrodent safety species (dogs and monkeys). In the current paper, we wish to report our efforts to understand and improve the poor PK in nonrodents and development of a new isoquinolinone subseries that led to identification of a new development candidate, CRA-680 (44). This compound was efficacious in both a house dust mouse model of allergic lung inflammation (40 mg/kg qd) as well as a guinea pig allergen challenge model of lung inflammation (20 mg/kg bid).

  DOI：

  10.1021/jm401509e