(4-Chloro-phenyl)-[4-(3-chloro-phenyl)-2-(2,2-dimethoxy-ethylamino)-quinolin-6-yl]-methanone | 280143-37-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: (4-Chloro-phenyl)-[4-(3-chloro-phenyl)-2-(2,2-dimethoxy-ethylamino)-quinolin-6-yl]-methanone
• 英文别名: (4-Chlorophenyl)-[4-(3-chlorophenyl)-2-(2,2-dimethoxyethylamino)quinolin-6-yl]methanone
• CAS: 280143-37-5
• 化学式: C₂₆H₂₂Cl₂N₂O₃
• 分子量: 481.378
• InChiKey: JEAXFEHBEOWQOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (4-Chloro-phenyl)-[4-(3-chloro-phenyl)-2-(2,2-dimethoxy-ethylamino)-quinolin-6-yl]-methanone 在 正丁基锂 、 溶剂黄146 作用下， 以 四氢呋喃 、 xylene 为溶剂， 生成 5-(3-chlorophenyl)-α-(4-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-imidazol[1,2-a]quinoline-7-methanol
  参考文献：
  名称：

  Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors

  摘要：

  A series of (4-chlorophenyl)-alpha-(1-methyl-1H-imidazol-5-yl)azoloquinolines and -quinazolines was prepared. These compounds displayed potent Farnesyl Protein Transferase inhibitory activity and tetrazolo[1,5-a]quinazolines are promising agents for oral in vivo inhibition. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.08.080
• 作为产物：
  描述：

  N-[2-(3-chlorobenzoyl)-4-(4-chlorobenzoyl)phenyl]acetamide 在 potassium tert-butylate 、 三氯氧磷 作用下， 以 乙二醇二甲醚 为溶剂， 生成 (4-Chloro-phenyl)-[4-(3-chloro-phenyl)-2-(2,2-dimethoxy-ethylamino)-quinolin-6-yl]-methanone
  参考文献：
  名称：

  Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors

  摘要：

  A series of (4-chlorophenyl)-alpha-(1-methyl-1H-imidazol-5-yl)azoloquinolines and -quinazolines was prepared. These compounds displayed potent Farnesyl Protein Transferase inhibitory activity and tetrazolo[1,5-a]quinazolines are promising agents for oral in vivo inhibition. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.08.080

文献信息

• Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors
  作者：Patrick Angibaud、Xavier Bourdrez、David W. End、Eddy Freyne、Michel Janicot、Patricia Lezouret、Yannick Ligny、Geert Mannens、Siegrid Damsch、Laurence Mevellec、Christophe Meyer、Philippe Muller、Isabelle Pilatte、Virginie Poncelet、Bruno Roux、Gerda Smets、Jacky Van Dun、Pieter Van Remoortere、Marc Venet、Walter Wouters

  DOI：10.1016/j.bmcl.2003.08.080

  日期：2003.12

  A series of (4-chlorophenyl)-alpha-(1-methyl-1H-imidazol-5-yl)azoloquinolines and -quinazolines was prepared. These compounds displayed potent Farnesyl Protein Transferase inhibitory activity and tetrazolo[1,5-a]quinazolines are promising agents for oral in vivo inhibition. (C) 2003 Elsevier Ltd. All rights reserved.