p-Benzyloxybenzoesaeure-n-dodecylester | 56441-74-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-Benzyloxybenzoesaeure-n-dodecylester
• 英文别名: Dodecyl 4-phenylmethoxybenzoate
• CAS: 56441-74-8
• 化学式: C₂₆H₃₆O₃
• 分子量: 396.57
• InChiKey: GALZJMUIVBBAOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.3
• 重原子数：
  29
• 可旋转键数：
  16
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  羟苯十二酯 、 氯化苄 在 sodium ethanolate 作用下， 生成 p-Benzyloxybenzoesaeure-n-dodecylester
  参考文献：
  名称：

  Hypolipidemic analogs of ethyl 4-benzyloxybenzoate

  摘要：

  A series of compounds related to ethyl 4-benzyloxybenzoate was synthesized and evaluated for potential hypolipidemic activity in rats. Structure--activity relationships are discussed in terms of cholesterol-lowering activity together with effects on weight gain and liver lipids. A number of the compounds inhibited cholesterol and free fatty acid biosynthesis from [1-14C]acetate in rat liver slices in vitro. Ethyl 4-benzyloxybenzoate, ethyl-4-benzyloxybenzoic acid, ethyl 4-p-bromobenzyloxybenzoates, and 4-o-methoxybenzyloxyphenyl acetate exhibited the most favorable spectrum of activity.

  DOI：

  10.1021/jm00221a007

文献信息

• Hypolipidemic analogs of ethyl 4-benzyloxybenzoate
  作者：Keith H. Baggaley、Robin Fears、Richard M. Hindley、Brian Morgan、Elspeth Murrell、David E. Thorne

  DOI：10.1021/jm00221a007

  日期：1977.11

  A series of compounds related to ethyl 4-benzyloxybenzoate was synthesized and evaluated for potential hypolipidemic activity in rats. Structure--activity relationships are discussed in terms of cholesterol-lowering activity together with effects on weight gain and liver lipids. A number of the compounds inhibited cholesterol and free fatty acid biosynthesis from [1-14C]acetate in rat liver slices in vitro. Ethyl 4-benzyloxybenzoate, ethyl-4-benzyloxybenzoic acid, ethyl 4-p-bromobenzyloxybenzoates, and 4-o-methoxybenzyloxyphenyl acetate exhibited the most favorable spectrum of activity.