10,10-Dimethyl-1,2,3,4,10,10a-hexahydropyrido[1,2-a]indole | 135673-39-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 10,10-Dimethyl-1,2,3,4,10,10a-hexahydropyrido[1,2-a]indole
• 英文别名: 10,10-dimethyl-7,8,9,9a-tetrahydro-6H-pyrido[1,2-a]indole
• CAS: 135673-39-1
• 化学式: C₁₄H₁₉N
• 分子量: 201.312
• InChiKey: VLRHNMARKIEKKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-benzyl-3,3-dimethyl-1,3-dihydro-indol-2-one 在 氨 、 叔丁基锂 、 lithium 、 sodium hydride 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 14.13h， 生成 10,10-Dimethyl-1,2,3,4,10,10a-hexahydropyrido[1,2-a]indole
  参考文献：
  名称：

  Intramolecular organolithium addition to indol-2(3H )-ones; an approach to the synthesis of pyrrolo[1,2-a]indoles and pyrido[1,2-a]indoles

  摘要：

  通过锂-卤素交换反应将3和10环化，随后用锂铝氢还原，生成吡咯并[1,2-a]吲哚11和13。对溴化物4a和4b进行类似处理，得到吡啶并[1,2-a]吲哚12a和12b。

  DOI：

  10.1039/a909548i

文献信息

• Intramolecular alkyllithium additions to lactams; a synthesis of 2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indoles (pyrrolo[1,2-a]indolemnes) related to mitomycins
  作者：John M. D. Storey、Clive McCarthy、Keith Jones

  DOI：10.1039/c39910000892

  日期：——

  Cyclisation of 5, 8, 10a and 10bvia their lithium derivatives followed by in situ reduction with lithium aluminium hydride gives pyrroloindolenines 2 and 9 and pyridinoindolenines 11a and 11b, respectively.

  5、8、10a和10b通过它们的锂衍生物环化，然后用氢化铝锂原位还原，分别得到吡咯并吲哚啉2和9以及吡啶并吲哚啉11a和11b。
• MONOFUNCTIONAL CARBOCYANINE DYES FOR IN VIVO AND IN VITRO IMAGING
  申请人：Hilderbrand Scott A.

  公开号：US20110286933A1

  公开（公告）日：2011-11-24

  The present invention provides symmetric carbocyanine dyes and dye precursors useful for fluorescence microscopy, and methods of making and using same.

  本发明提供了对称的碳氰染料和染料前体，可用于荧光显微镜技术，并提供制备和使用该染料的方法。
• US8916137B2
  申请人：——

  公开号：US8916137B2

  公开（公告）日：2014-12-23
• [EN] DYEING PROCESS USING A COMPOSITION COMPRISING A GLYCOSYL IRIDOID COMPOUND AND A NUCLEOPHILE OR AN AMINO OR THIO POLYMER, COMPOSITION AND DEVICES THEREFOR<br/>[FR] PROCÉDÉ DE COLORATION UTILISANT UNE COMPOSITION COMPRENANT UN COMPOSÉ IRIDOÏDE GLYCOSYLIQUE ET UN NUCLÉOPHILE OU UN POLYMÈRE AMINÉ OU THIOLÉ ET COMPOSITION ET DISPOSITIFS S'Y RAPPORTANT
  申请人：OREAL

  公开号：WO2013045701A2

  公开（公告）日：2013-04-04

  The present invention relates to a process of dyeing human keratin fibres by applying a composition, comprising, in a cosmetically acceptable medium: * a compound of the iridoid family of formula (I) below, or a plant extract comprising the same: formula (I) in which hydrogen, methyl, hydroxymethyl, aldehyde; -CO2R4 in which R4: hydrogen, C1-C2 alkyl; sugar; R2: a hydrogen atom, a hydroxyl radical, sugar radical; R3: hydrogen, hydroxyl, alkyloxy; R: sugar radical (aldose or derivative); integer ranging from 1 to 5; the compound(s) of formula (I) having undergone prior to or simultaneously with the dyeing process, a step consisting in replacing the radical R with a hydrogen atom; ** at least one particular nucleophilic compound or at least one amino or thio polymer, in an amino or thio polymer(s)/compound(s) of formulae (I) and/or (II) weight ratio of at least 0.01. The invention also relates to multi-compartment devices.
• [EN] DYE COMPOSITION COMPRISING A NON-GLYCOSYL IRIDOID COMPOUND AND A SPECIFIC NUCLEOPHILE OR AN AMINO OR THIO POLYMER, DYEING PROCESS, AND DEVICE THEREFOR<br/>[FR] COLORANT COMPRENANT UN COMPOSÉ IRIDOÏDE NON GLYCOSYLE ET UN NUCLÉOPHILE OU UN AMINO OU THIO POLYMÈRE, PROCÉDÉ DE COLORATION ET DISPOSITIF AFFÉRENT
  申请人：OREAL

  公开号：WO2013045702A2

  公开（公告）日：2013-04-04

  The present invention relates to a composition for dyeing human keratin fibres, comprising, in a cosmetically acceptable medium: * a compound of the formula (I) and/or of the formula (II) below, or a plant extract comprising the same: with R1 : hydrogen, (hydroxy)methyl, aldehyde; -CO2R4 and R4: hydrogen, alkyl; -CH2- glucose; R2: hydrogen, hydroxyl, glucose; R3: hydrogen, hydroxyl, alkyloxy; n ranging from 1 to 5; R5: -C02R'6 and R'6: hydrogen, alkyl, cation; ** at least one particular nucleophilic compound or at least one amino or thio polymer, in an amino or thio polymer(s)/compound(s) of formulae (I) and/or (II) weight ratio of at least 0.01, *** one or more particular organic or mineral salts. The invention also relates to a process using such a composition, and also to multi-compartment device.