2-((2-mercaptoethoxy)carbonyl)-2-methylpropane-1,3-diyl bis(5-azidopentanoate) | 1238384-33-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-((2-mercaptoethoxy)carbonyl)-2-methylpropane-1,3-diyl bis(5-azidopentanoate)
• 英文别名: 2-Sulfanylethyl 3-(5-azidopentanoyloxy)-2-(5-azidopentanoyloxymethyl)-2-methylpropanoate
• CAS: 1238384-33-2
• 化学式: C₁₇H₂₈N₆O₆S
• 分子量: 444.512
• InChiKey: GCTGRXRDTPDPCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  30
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  2-((2-mercaptoethoxy)carbonyl)-2-methylpropane-1,3-diyl bis(5-azidopentanoate) 、 2,4,6-三烯丙氧基-1,3,5-三嗪 在 4-二甲氨基吡啶 作用下， 以 四氢呋喃 为溶剂， 反应 0.75h， 生成
  参考文献：
  名称：

  Pushing the Limits for Thiol−Ene and CuAAC Reactions: Synthesis of a 6th Generation Dendrimer in a Single Day

  摘要：

  Dendrimer synthesis should not be tedious and time-consuming. By utilizing an AB(2)-CD2 approach and having orthogonal, "clickable" groups on each monomer, the time for dendrimer assembly can be drastically reduced. This was shown by preparation of a sixth generation dendrimer from starting monomer units in a single day.

  DOI：

  10.1021/ma101242u
• 作为产物：
  描述：

  2,2'-(2,2'-disulfanediylbis(ethane-2,1-diyl)bis(oxy))bis(oxomethylene)bis-(2-methylpropane3,2,1-triyl) tetrakis(5-azidopentanoate) 在 1,4-dithio-D,L-threitol 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.25h， 以80%的产率得到2-((2-mercaptoethoxy)carbonyl)-2-methylpropane-1,3-diyl bis(5-azidopentanoate)
  参考文献：
  名称：

  Pushing the Limits for Thiol−Ene and CuAAC Reactions: Synthesis of a 6th Generation Dendrimer in a Single Day

  摘要：

  Dendrimer synthesis should not be tedious and time-consuming. By utilizing an AB(2)-CD2 approach and having orthogonal, "clickable" groups on each monomer, the time for dendrimer assembly can be drastically reduced. This was shown by preparation of a sixth generation dendrimer from starting monomer units in a single day.

  DOI：

  10.1021/ma101242u

文献信息

• CYCLOPROPENIUM POLYMERS AND METHODS FOR MAKING THE SAME
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US20150175727A1

  公开（公告）日：2015-06-25

  The present invention provides, inter alia, a process for incorporating a cyclopropenium ion into a polymeric system. Processes for making cross-linked polymers, linear polymers, and dendritic polymers, as well as for incorporating a cyclopropenium ion onto a preformed polymer are also provided. Further provided are stable, polycationic compounds, various polymers that contain stable cyclopropenium cations, and substrates containing such polymers. The use of these polymers in water purification systems, antimicrobial coatings, ion-transport membranes, cell supports, drug delivery vehicles, and gene therapeutic vectors are also provided.

  本发明提供了将环丙烯阳离子引入到聚合体系中的方法。还提供了制备交联聚合物、线性聚合物和树枝状聚合物的方法，以及将环丙烯阳离子引入到预制聚合物上的方法。此外，还提供了稳定的多阳离子化合物，包含稳定的环丙烯阳离子的各种聚合物，以及含有这些聚合物的基底。此外，还提供了在水处理系统、抗微生物涂层、离子传输膜、细胞支持、药物传递载体和基因治疗载体中使用这些聚合物的方法。
• US9758606B2
  申请人：——

  公开号：US9758606B2

  公开（公告）日：2017-09-12