2,2'-(2,2'-disulfanediylbis(ethane-2,1-diyl)bis(oxy))bis(oxomethylene)bis-(2-methylpropane3,2,1-triyl) tetrakis(5-azidopentanoate) | 1238384-32-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,2'-(2,2'-disulfanediylbis(ethane-2,1-diyl)bis(oxy))bis(oxomethylene)bis-(2-methylpropane3,2,1-triyl) tetrakis(5-azidopentanoate)
• CAS: 1238384-32-1
• 化学式: C₃₄H₅₄N₁₂O₁₂S₂
• 分子量: 887.008
• InChiKey: UKIBHUMNAWEYMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.56
• 重原子数：
  60.0
• 可旋转键数：
  37.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  352.84
• 氢给体数：
  0.0
• 氢受体数：
  18.0

反应信息

• 作为反应物：
  描述：

  2,2'-(2,2'-disulfanediylbis(ethane-2,1-diyl)bis(oxy))bis(oxomethylene)bis-(2-methylpropane3,2,1-triyl) tetrakis(5-azidopentanoate) 在 1,4-dithio-D,L-threitol 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.25h， 以80%的产率得到2-((2-mercaptoethoxy)carbonyl)-2-methylpropane-1,3-diyl bis(5-azidopentanoate)
  参考文献：
  名称：

  Pushing the Limits for Thiol−Ene and CuAAC Reactions: Synthesis of a 6th Generation Dendrimer in a Single Day

  摘要：

  Dendrimer synthesis should not be tedious and time-consuming. By utilizing an AB(2)-CD2 approach and having orthogonal, "clickable" groups on each monomer, the time for dendrimer assembly can be drastically reduced. This was shown by preparation of a sixth generation dendrimer from starting monomer units in a single day.

  DOI：

  10.1021/ma101242u
• 作为产物：
  描述：

  2,2'-disulfanediylbis(ethane-2,1-diyl) bis(2,2,5-trimethyl-1,3-dioxane-5-carboxylate) 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 2,2'-(2,2'-disulfanediylbis(ethane-2,1-diyl)bis(oxy))bis(oxomethylene)bis-(2-methylpropane3,2,1-triyl) tetrakis(5-azidopentanoate)
  参考文献：
  名称：

  Pushing the Limits for Thiol−Ene and CuAAC Reactions: Synthesis of a 6th Generation Dendrimer in a Single Day

  摘要：

  Dendrimer synthesis should not be tedious and time-consuming. By utilizing an AB(2)-CD2 approach and having orthogonal, "clickable" groups on each monomer, the time for dendrimer assembly can be drastically reduced. This was shown by preparation of a sixth generation dendrimer from starting monomer units in a single day.

  DOI：

  10.1021/ma101242u