ethyl 2-{2-[2-(2-aminoethoxy)-ethoxy]-ethoxy}acetate | 118988-07-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 2-{2-[2-(2-aminoethoxy)-ethoxy]-ethoxy}acetate
• 英文别名: Ethyl 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)acetate；ethyl 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]acetate
• CAS: 118988-07-1
• 化学式: C₁₀H₂₁NO₅
• 分子量: 235.28
• InChiKey: AKMIHBVFDKSWKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  16
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  80
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  ethyl 2-{2-[2-(2-aminoethoxy)-ethoxy]-ethoxy}acetate 在 palladium on activated charcoal 4-二甲氨基吡啶 、 氢气 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 ethyl 2-[2-[2-[2-[[2-[[3-amino-5-[butyl-[2-[2-[2-[2-(2-ethoxy-2-oxoethoxy)ethoxy]ethoxy]ethylamino]-2-oxoethyl]carbamoyl]benzoyl]-butylamino]acetyl]amino]ethoxy]ethoxy]ethoxy]acetate
  参考文献：
  名称：

  The “chundle” approach to molecular channels synthesis of a macrocycle-based molecular bundle

  摘要：

  DOI：

  10.1016/s0040-4039(00)82119-x
• 作为产物：
  描述：

  ethyl [2-[2-(2-azidoethoxy)ethoxy]ethoxy]acetate 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 ethyl 2-{2-[2-(2-aminoethoxy)-ethoxy]-ethoxy}acetate
  参考文献：
  名称：

  固体载体上阿尔茨海默氏体配体的合成与结合研究

  摘要：

  氨基吡唑衍生物构成第一类合理设计的非肽类β-折叠配体。在这里，我们描述了用于合成和亲和力测试的双重固相方案。所提出的四种杂合化合物的固相合成依赖于Fmoc策略，并通过从有机溶液中以纯净形式沉淀出最终产物来规避随后的HPLC纯化。具有内部二肽和四肽桥的六肽和八肽侧基现在可以高产率地用于化合物文库的组合合成，以进行高通量筛选。耐酸性PAM上的固相肽合成（SPPS）使我们在PMB脱保护后，可以将固定状态下的游离氨基吡唑结合位点进行荧光标记肽的珠上检测。从荧光发射强度的降低，可以通过简单地应用质量作用定律，通过参考曲线计算出各个结合常数。令人高兴的是，即使对于几乎不溶于水的那些配体，也可以定量地监测宿主/客体的复合。

  DOI：

  10.1021/jo061918x

文献信息

• Compounds and Their Use in Treating Cancer
  申请人：AstraZeneca AB

  公开号：US20190194190A1

  公开（公告）日：2019-06-27

  The specification generally relates to compounds of Formula (I): and pharmaceutically acceptable salts and prodrugs thereof, where R 1 , R 4 , R 5 , R 6 , R 7 , Linker, X, Y, A, G, D and E have any of the meanings defined herein. This specification also relates to the use of such compounds and pharmaceutically acceptable salts and prodrugs thereof in methods of treatment of the human or animal body, for example in prevention or treatment of cancer. This specification also relates to processes and intermediate compounds involved in the preparation of such compounds and to pharmaceutical compositions containing them.

  本说明书一般涉及公式(I)的化合物： 以及药学上可接受的盐和前药，其中R1、R4、R5、R6、R7、Linker、X、Y、A、G、D和E具有此处定义的任何含义。本说明书还涉及将此类化合物以及药学上可接受的盐和前药用于治疗人体或动物体的方法，例如用于预防或治疗癌症。本说明书还涉及制备此类化合物涉及的工艺和中间化合物，以及含有它们的药物组合物。
• Synthesis and Binding Studies of Alzheimer Ligands on Solid Support
  作者：Petra Rzepecki、Nina Geib、Manuel Peifer、Frank Biesemeier、Thomas Schrader

  DOI：10.1021/jo061918x

  日期：2007.5.1

  Aminopyrazole derivatives constitute the first class of nonpeptidic rationally designed β-sheet ligands. Here we describe a double solid-phase protocol for both synthesis and affinity testing. The presented solid-phase synthesis of four types of hybrid compounds relies on the Fmoc strategy and circumvents subsequent HPLC purification by precipitating the final product from organic solution in pure

  氨基吡唑衍生物构成第一类合理设计的非肽类β-折叠配体。在这里，我们描述了用于合成和亲和力测试的双重固相方案。所提出的四种杂合化合物的固相合成依赖于Fmoc策略，并通过从有机溶液中以纯净形式沉淀出最终产物来规避随后的HPLC纯化。具有内部二肽和四肽桥的六肽和八肽侧基现在可以高产率地用于化合物文库的组合合成，以进行高通量筛选。耐酸性PAM上的固相肽合成（SPPS）使我们在PMB脱保护后，可以将固定状态下的游离氨基吡唑结合位点进行荧光标记肽的珠上检测。从荧光发射强度的降低，可以通过简单地应用质量作用定律，通过参考曲线计算出各个结合常数。令人高兴的是，即使对于几乎不溶于水的那些配体，也可以定量地监测宿主/客体的复合。
• [EN] NEW COMPOUNDS FOR THE TREATMENT OF DISEASES RELATED TO PROTEIN MISFOLDING<br/>[FR] NOUVEAUX COMPOSÉS POUR LE TRAITEMENT DE MALADIES LIÉES À UN MAUVAIS REPLIEMENT DE PROTÉINES
  申请人：UNIV DUISBURG ESSEN

  公开号：WO2011050864A1

  公开（公告）日：2011-05-05

  The present invention relates to the field of protein misfolding diseases and thus to diseases which are associated with or induced by abnormal or pathogenic three-dimensional folding of proteins and/or peptides or which are linked to pathogenic conformational changes of proteins and/or peptides, such as Alzheimer's disease. Particularly, the present invention provides novel trimeric pyrazole compounds, which exhibit a therapeutic effectiveness in regard to the aforementioned protein misfolding diseases, and refers to their use for the treatment of such protein misfolding diseases, especially neurodegenerative diseases as well as to medicaments or pharmaceutical compositions comprising these compounds.

  本发明涉及蛋白质错折疾病领域，因此涉及与异常或致病性蛋白质和/或肽的三维折叠相关或诱导的疾病，或与致病性蛋白质和/或肽的构象变化相关的疾病，如阿尔茨海默病。具体地，本发明提供了新型三聚吡唑化合物，这些化合物在治疗上述蛋白质错折疾病方面表现出治疗有效性，并涉及其用于治疗此类蛋白质错折疾病，特别是神经退行性疾病，以及包含这些化合物的药物或制剂组合物。
• COMPOUNDS FOR THE TREATMENT OF DISEASES RELATED TO PROTEIN MISFOLDING
  申请人：Schrader Thomas

  公开号：US20120270795A1

  公开（公告）日：2012-10-25

  The present invention relates to the field of protein misfolding diseases and thus to diseases which are associated with or induced by abnormal or pathogenic three-dimensional folding of proteins and/or peptides or which are linked to pathogenic conformational changes of proteins and/or peptides, such as Alzheimer's disease. Particularly, the present invention provides novel trimeric pyrazole compounds, which exhibit a therapeutic effectiveness in regard to the aforementioned protein misfolding diseases, and refers to their use for the treatment of such protein misfolding diseases, especially neurodegenerative diseases as well as to medicaments or pharmaceutical compositions comprising these compounds.

  本发明涉及蛋白质错折疾病领域，因此涉及与蛋白质和/或肽的异常或致病三维折叠相关或诱导的疾病，以及与蛋白质和/或肽的致病构象变化相关的疾病，如阿尔茨海默病。特别地，本发明提供了新型三聚吡唑化合物，其在治疗上述蛋白质错折疾病方面具有治疗效果，并涉及其用于治疗这种蛋白质错折疾病，特别是神经退行性疾病，以及包含这些化合物的药物或制药组合物。
• Compounds for the treatment of diseases related to protein misfolding
  申请人：Schrader Thomas

  公开号：US08481494B2

  公开（公告）日：2013-07-09

  The present invention relates to the field of protein misfolding diseases and thus to diseases which are associated with or induced by abnormal or pathogenic three-dimensional folding of proteins and/or peptides or which are linked to pathogenic conformational changes of proteins and/or peptides, such as Alzheimer's disease. Particularly, the present invention provides novel trimeric pyrazole compounds, which exhibit a therapeutic effectiveness in regard to the aforementioned protein misfolding diseases, and refers to their use for the treatment of such protein misfolding diseases, especially neurodegenerative diseases as well as to medicaments or pharmaceutical compositions comprising these compounds.

  本发明涉及蛋白质错折性疾病领域，因此涉及与或由蛋白质和/或肽的异常或致病性三维折叠相关或诱导的疾病，或与蛋白质和/或肽的致病性构象变化相关的疾病，如阿尔茨海默病等。特别地，本发明提供了新型三聚吡唑化合物，其在上述蛋白质错折性疾病方面表现出治疗有效性，并涉及其用于治疗此类蛋白质错折性疾病，特别是神经退行性疾病，以及包括这些化合物的药物或制剂。