PMQA | 1447257-36-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: PMQA
• 英文别名: N-[(E)-pyridin-3-ylmethylidene]quinolin-3-amine
• CAS: 1447257-36-4
• 化学式: C₁₅H₁₁N₃
• 分子量: 233.272
• InChiKey: VVWMGEZLUIGLMJ-LICLKQGHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.38
• 重原子数：
  18.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.14
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  PMQA 、 cobalt(II) chloride 以 乙醇 为溶剂， 反应 1.0h， 生成 [Co(PMQA)Cl₂]
  参考文献：
  名称：

  Antibacterial and Thermal Study of Selected Transition Metal Complexes of N-[(E)-pyridin-3- ylmethylidene]quinolin-3-amine (PMQA)

  摘要：

  N-[(E)-pyridin-3-ylmethylidene]quinolin-3-amine (PMQA), a derivative of quinoline and its complexes with Co(II), Ni(II), Cu(II), and Zn(II) chlorides were synthesized and tested for their antimicrobial activity. The PMQA provided the N,N donor sites to the transition metals hence imparting novelty and stability to the complexes. The structures of the complexes along with the ligand were characterized by physical methods such as elemental analysis, UV-Vis spectra,1H-NMR, IR, and conductance studies. Thermal degradation pattern was examined with TG/DT analysis. Antimicrobial activities were studied with gram-positive bacteria, which included Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermis, and Streptococcus pneumonia, and Pseudomonas aeruginosa, Salmonella typhi, and Escherichia coli represented gram-negative bacteria. The prepared compounds showed high activity against Bacillus subtilis as compared to the rest of the bacterial species.

  DOI：

  10.1080/15533174.2012.754769
• 作为产物：
  描述：

  3-吡啶甲醛 、 3-氨基喹啉 在 硫酸 作用下， 以 乙醇 为溶剂， 反应 0.03h， 以69%的产率得到PMQA
  参考文献：
  名称：

  Antibacterial and Thermal Study of Selected Transition Metal Complexes of N-[(E)-pyridin-3- ylmethylidene]quinolin-3-amine (PMQA)

  摘要：

  N-[(E)-pyridin-3-ylmethylidene]quinolin-3-amine (PMQA), a derivative of quinoline and its complexes with Co(II), Ni(II), Cu(II), and Zn(II) chlorides were synthesized and tested for their antimicrobial activity. The PMQA provided the N,N donor sites to the transition metals hence imparting novelty and stability to the complexes. The structures of the complexes along with the ligand were characterized by physical methods such as elemental analysis, UV-Vis spectra,1H-NMR, IR, and conductance studies. Thermal degradation pattern was examined with TG/DT analysis. Antimicrobial activities were studied with gram-positive bacteria, which included Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermis, and Streptococcus pneumonia, and Pseudomonas aeruginosa, Salmonella typhi, and Escherichia coli represented gram-negative bacteria. The prepared compounds showed high activity against Bacillus subtilis as compared to the rest of the bacterial species.

  DOI：

  10.1080/15533174.2012.754769

文献信息

• Antibacterial and Thermal Study of Selected Transition Metal Complexes of <i>N</i>-[(<i>E</i>)-pyridin-3- ylmethylidene]quinolin-3-amine (PMQA)
  作者：Alia Faiz、Robila Nawaz、Nauman Ali

  DOI：10.1080/15533174.2012.754769

  日期：2013.7.3

  N-[(E)-pyridin-3-ylmethylidene]quinolin-3-amine (PMQA), a derivative of quinoline and its complexes with Co(II), Ni(II), Cu(II), and Zn(II) chlorides were synthesized and tested for their antimicrobial activity. The PMQA provided the N,N donor sites to the transition metals hence imparting novelty and stability to the complexes. The structures of the complexes along with the ligand were characterized by physical methods such as elemental analysis, UV-Vis spectra,1H-NMR, IR, and conductance studies. Thermal degradation pattern was examined with TG/DT analysis. Antimicrobial activities were studied with gram-positive bacteria, which included Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermis, and Streptococcus pneumonia, and Pseudomonas aeruginosa, Salmonella typhi, and Escherichia coli represented gram-negative bacteria. The prepared compounds showed high activity against Bacillus subtilis as compared to the rest of the bacterial species.