2,3,4-tri-O-benzoyl-α-L-rhamnopyranosyl-(1->4)-2,3,6-tri-O-benzoyl-β-D-glucopyranosyl-(1->6)-1,2,3,4-tetra-O-benzoyl-α-D-glucopyranosyl trichloroacetimidate | 1207994-51-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,3,4-tri-O-benzoyl-α-L-rhamnopyranosyl-(1->4)-2,3,6-tri-O-benzoyl-β-D-glucopyranosyl-(1->6)-1,2,3,4-tetra-O-benzoyl-α-D-glucopyranosyl trichloroacetimidate
• 英文别名: Bz(-2)[Bz(-3)][Bz(-4)]Rha(a1-4)[Bz(-2)][Bz(-3)][Bz(-6)]Glc(b1-6)[Bz(-2)][Bz(-3)][Bz(-4)]Glc(a)-O-C(NH)CCl3；[(2R,3R,4S,5R,6R)-4,5-dibenzoyloxy-3-[(2S,3R,4R,5S,6S)-3,4,5-tribenzoyloxy-6-methyloxan-2-yl]oxy-6-[[(2R,3R,4S,5R,6R)-3,4,5-tribenzoyloxy-6-(2,2,2-trichloroethanimidoyl)oxyoxan-2-yl]methoxy]oxan-2-yl]methyl benzoate
• CAS: 1207994-51-1
• 化学式: C₈₃H₆₈Cl₃NO₂₄
• 分子量: 1569.8
• InChiKey: JTODRXHPZBWHOL-WKWDYEDCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16.2
• 重原子数：
  111
• 可旋转键数：
  35
• 环数：
  12.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  316
• 氢给体数：
  1
• 氢受体数：
  25

反应信息

• 作为反应物：
  描述：

  3,4-di-O-benzoyl-2-O-levulinoyl-β-D-xylopyranosyl trichloroacetimidate 、 2,3,4-tri-O-benzoyl-α-L-rhamnopyranosyl-(1->4)-2,3,6-tri-O-benzoyl-β-D-glucopyranosyl-(1->6)-1,2,3,4-tetra-O-benzoyl-α-D-glucopyranosyl trichloroacetimidate 、 oleanolic acid trityl ester 在 三氟甲磺酸三甲基硅酯 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 以65%的产率得到3-O-(3,4-di-O-benzoyl-2-O-levulinoyl-β-D-xylopyranosyl)-oleanolic acid 2,3,4-tri-O-benzoyl-α-L-rhamnopyranosyl-(1->4)-2,3,6-tri-O-benzoyl-β-D-glucopyranosyl-(1->6)-1,2,3,4-tetra-O-benzoyl-α-D-glucopyranosyl ester
  参考文献：
  名称：

  Efficient Synthesis of Flaccidoside II, a Bioactive Component of Chinese Folk Medicine Di Wu

  摘要：

  A bidesmosidic triterpene saponin, flaccidoside II, which was isolated from Di Wu, a Chinese folk medicine from dry rhizome of Anemone flaccida Fr. Schmidt, was efficiently synthesized in a convergent approach. We employed two glycosyl trichloroacetimidate donors in a one-pot reaction as a key step.

  DOI：

  10.1080/07328300903260192
• 作为产物：
  描述：

  、 三氯乙腈 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以109 mg的产率得到2,3,4-tri-O-benzoyl-α-L-rhamnopyranosyl-(1->4)-2,3,6-tri-O-benzoyl-β-D-glucopyranosyl-(1->6)-1,2,3,4-tetra-O-benzoyl-α-D-glucopyranosyl trichloroacetimidate
  参考文献：
  名称：

  Efficient Synthesis of Flaccidoside II, a Bioactive Component of Chinese Folk Medicine Di Wu

  摘要：

  A bidesmosidic triterpene saponin, flaccidoside II, which was isolated from Di Wu, a Chinese folk medicine from dry rhizome of Anemone flaccida Fr. Schmidt, was efficiently synthesized in a convergent approach. We employed two glycosyl trichloroacetimidate donors in a one-pot reaction as a key step.

  DOI：

  10.1080/07328300903260192