6-氯-2-甲氧基-N-丙基-吖啶-9-胺 | 79953-28-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 6-氯-2-甲氧基-N-丙基-吖啶-9-胺
• 英文名称: 6-chloro-2-methoxy-9-(propylamino)acridine
• 英文别名: 9-Acridinamine, 6-chloro-2-methoxy-N-propyl-；6-chloro-2-methoxy-N-propylacridin-9-amine
• CAS: 79953-28-9
• 化学式: C₁₇H₁₇ClN₂O
• 分子量: 300.788
• InChiKey: LDADDILQPHUTNC-UHFFFAOYSA-N

物化性质

• 沸点：
  477.9±35.0 °C(Predicted)
• 密度：
  1.256±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  34.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  正丙胺 、 6-氯-2-甲氧基-9-苯氧基吖啶 以 various solvent(s) 为溶剂， 反应 2.0h， 以45%的产率得到6-氯-2-甲氧基-N-丙基-吖啶-9-胺
  参考文献：
  名称：

  Synthetic models related to DNA intercalating molecules: comparison between quinacrine and chloroquine in their ring-ring interaction with adenine and thymine

  摘要：

  DOI：

  10.1021/ja00367a019

文献信息

• Dimeric quinacrine derivatives as autophagy inhibitors for cancer therapy
  申请人：THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：US10774047B2

  公开（公告）日：2020-09-15

  The invention provides dimeric quinacrine derivatives and related compounds and compositions, methods of treatment and syntheses. The novel compounds exhibit unexpected anticancer activity and are useful in the treatment of a variety of autophagy-related disorders.

  本发明提供了二聚喹啉衍生物和相关化合物及组合物、治疗方法和合成方法。这些新型化合物具有意想不到的抗癌活性，可用于治疗多种自噬相关疾病。
• [EN] COMPOUNDS THAT BIND NON-CANONICAL G-QUADRUPLEX STRUCTURES AND METHODS OF MAKING AND USING THE SAME<br/>[FR] COMPOSÉS QUI SE LIENT À DES STRUCTURES G-QUADRUPLEXES NON CANONIQUES ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：[en]THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：WO2022261296A1

  公开（公告）日：2022-12-15

  Small molecule compounds that selectively bind to non-canonical G-quadruplex (G4) structures, such as G4s in DNA found in various types of genes described herein, along with methods of using the compounds to reduce or inhibit protein (e.g., N-Myc protein) expression in cells, such as cancer cells. The compounds have a structure according to formulas described herein, or a stereoisomer, tautomer, or pharmaceutically effective salt or ester thereof.