2-Cyclopropylmethoxymethyl-oxirane | 88135-04-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 英文名称: 2-Cyclopropylmethoxymethyl-oxirane
• 英文别名: 2-[(Cyclopropylmethoxy)methyl]oxirane；2-(cyclopropylmethoxymethyl)oxirane
• CAS: 88135-04-0
• 化学式: C₇H₁₂O₂
• mdl: MFCD11136684
• 分子量: 128.171
• InChiKey: FKGPXXGPALLSPI-UHFFFAOYSA-N

物化性质

• 沸点：
  175.0±8.0 °C(Predicted)
• 密度：
  1.090±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Cyclopropylmethoxymethyl-oxirane 在 正丁基锂 、 sodium hydride 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 生成
  参考文献：
  名称：

  EP3851436

  摘要：

  公开号：
• 作为产物：
  描述：

  羟甲基环丙烷 、 环氧氯丙烷 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 生成 2-Cyclopropylmethoxymethyl-oxirane
  参考文献：
  名称：

  新規ヘテロ芳香族アミド誘導体又はその塩からなる医薬

  摘要：

  本文提供了一种用于治疗或预防与疼痛相关疾病、瘙痒相关疾病、自主神经相关疾病等的与电位依赖性钠通道（Nav1.7）有关的化合物或其药物组合物。具体化合物及其包含的药物组合物如下所示。【选择图】无

  公开号：

  JP2021138690A

文献信息

• Synthesis and .beta.-adrenergic blocking activity of new aliphatic and alicyclic oxime ethers
  作者：Mohamed Bouzoubaa、Gerard Leclerc、Nicole Decker、Jean Schwartz、Guy Andermann

  DOI：10.1021/jm00376a011

  日期：1984.10

  We describe the synthesis and pharmacological properties of two new series of aliphatic and alicyclic beta-adrenergic blockers, most of them containing a cyclopropyl ring. They belong either to 2-hydroxy-3-(tert-butylamino)propyl ether A or 2-hydroxy-3-tert-(butylamino)propyl ketoxime ether B derivatives. The O-[2-hydroxy-3-(tert-butylamino)propyl] dicyclopropyl ketoxime 5 exhibited a beta-adrenergic

  我们描述了两个新系列的脂肪族和脂环族β-肾上腺素能阻滞剂的合成和药理性质，其中大多数含有环丙基环。它们属于2-羟基-3-（叔丁基氨基）丙基醚A或2-羟基-3-叔-（丁基氨基）丙基酮肟醚B衍生物。O- [2-羟基-3-（叔丁基氨基）丙基]二环丙基酮肟5表现出与普萘洛尔相当的β-肾上腺素能拮抗剂活性。发现酮肟醚B通常显示出比相应的醚A更高的效力。我们证实，芳香核的存在对于β-肾上腺素活性不是至关重要的。讨论了这些系列之间的构效关系。
• 新規ヘテロ芳香族アミド誘導体又はその塩からなる医薬
  申请人：科研製薬株式会社

  公开号：JP2021138690A

  公开（公告）日：2021-09-16

  【課題】疼痛を伴う疾患、掻痒を伴う疾患、自律神経関連疾患等の、電位依存性ナトリウムチャネル(Nav1.7)が関与する疾患を治療又は予防するのに有用な化合物又はその医薬組成物を提供する。【解決手段】下式で例示される化合物、及びそれを含む医薬組成物。【選択図】なし

  本文提供了一种用于治疗或预防与疼痛相关疾病、瘙痒相关疾病、自主神经相关疾病等的与电位依赖性钠通道（Nav1.7）有关的化合物或其药物组合物。具体化合物及其包含的药物组合物如下所示。【选择图】无
• Epoxides as Dual-Functionalized Alkylating Reagents in Catellani Reactions for the Assembly of Heterocycles
  作者：Hong-Gang Cheng、Qianghui Zhou、Chenggui Wu

  DOI：10.1055/s-0039-1690779

  日期：2020.6

  acid that permits the use of epoxides as dual-functionalized alkylating reagents in Catellani-type reactions for the assembly of heterocycles. Salient features of this research include readily available substrates, use of the potassium salt of 5-norbornene-2-carboxylic acid as a catalytic mediator as well as a base, and excellent regioselectivity for the cleavage of epoxides. This mild, chemoselective

  报道了一种协同催化系统，由 Pd 与二环己基（2',4',6'-三异丙基联苯-2-基）膦（XPhos）和 5-降冰片烯-2-羧酸的钾盐组成的络合物，允许在用于组装杂环的 Catellani 型反应中使用环氧化物作为双官能化烷基化试剂。这项研究的显着特点包括容易获得的底物、使用 5-降冰片烯-2-羧酸的钾盐作为催化介质和碱，以及出色的环氧化物裂解区域选择性。这种温和、化学选择性、可扩展、原子和步骤经济的协议为异色满和 2,3-二氢苯并呋喃支架的组装提供了一种直接的方法。
• POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF
  申请人：Ma Minglin

  公开号：US20130302401A1

  公开（公告）日：2013-11-14

  A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.
• CONSOLIDATING COMPOSITION FOR TREATMENT OF A SUBTERRANEAN FORMATION
  申请人：Halliburton Energy Services, Inc.

  公开号：US20160272872A1

  公开（公告）日：2016-09-22

  Various embodiments disclosed relate to compositions for treating a subterranean formation and methods of using same, such as for consolidation. In various embodiments, the present invention provides a method of treating a subterranean formation, the method including obtaining or providing a composition. The composition includes an aryl component including at least one of an aryldicarboxylic acid, an ester thereof, a salt thereof, and an acid halide thereof. The composition includes an amine or epoxide component that includes at least one of component A and component B. Component A is a linear diepoxide, a poly(alkylamine), or a combination thereof. Component B is an alkoxy- or hydroxy-substituted silane including an epoxy group, an alkoxy- or hydroxy-substituted silane including an amine group, or a combination thereof. The method also includes placing the composition in a subterranean formation.