1-(4-methoxyphenyl)-7,7-dimethyl-2-phenyl-1,2,3,4,5,6,7,8-octahydroquinoline-4,5-dione | 663938-04-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(4-methoxyphenyl)-7,7-dimethyl-2-phenyl-1,2,3,4,5,6,7,8-octahydroquinoline-4,5-dione
• 英文别名: 2,3,7,8-Tetrahydro-1H,6H-quinoline-4,5-dione, 1-(4-methoxyphenyl)-7,7-dimethyl-2-phenyl-；1-(4-methoxyphenyl)-7,7-dimethyl-2-phenyl-2,3,6,8-tetrahydroquinoline-4,5-dione
• CAS: 663938-04-3
• 化学式: C₂₄H₂₅NO₃
• 分子量: 375.467
• InChiKey: MGGXXRBLJQWKKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-(4-methoxyphenylamino)-5,5-dimethyl-2-[(E)-3-phenylprop-2-enoyl]cyclohex-2-en-1-one 以 甲苯 为溶剂， 以67%的产率得到1-(4-methoxyphenyl)-7,7-dimethyl-2-phenyl-1,2,3,4,5,6,7,8-octahydroquinoline-4,5-dione
  参考文献：
  名称：

  Synthesis of exo- and endocyclic enamino derivatives of 2-(3-arylprop-2-enoyl)cyclohexane-1,3-diones

  摘要：

  Condensation of 2-acetylcyclohexane-1,3-diones with aromatic aldehydes in the presence of piperidine, pyrrolidine, hexamethyleneimine, or morpholine gave the corresponding 2-(3-arylprop-2-enoyl)cyclohexane-1,3-diones as the major products and 2-[3-aryl-1-cycloalkylaminoprop-2-en-1-ylidene]cyclohexane1,3-diones as minor ones. Endocyclic enamino derivatives were synthesized in two steps through enol methyl ethers which reacted with amines. Endocyclic enamino derivatives of 2-(3-arylprop-2-enoyl) cyclohexane-1,3-diones containing an aryl group on the nitrogen atom readily underwent cyclization to 1,2,3,4,5,6,7,8-octa-hydroquinoline-4,5-dione derivatives.

  DOI：

  10.1134/s1070428011030018

文献信息

• Synthesis of exo- and endocyclic enamino derivatives of 2-(3-arylprop-2-enoyl)cyclohexane-1,3-diones
  作者：D. B. Rubinov、I. L. Rubinova、F. A. Lakhvich

  DOI：10.1134/s1070428011030018

  日期：2011.3

  Condensation of 2-acetylcyclohexane-1,3-diones with aromatic aldehydes in the presence of piperidine, pyrrolidine, hexamethyleneimine, or morpholine gave the corresponding 2-(3-arylprop-2-enoyl)cyclohexane-1,3-diones as the major products and 2-[3-aryl-1-cycloalkylaminoprop-2-en-1-ylidene]cyclohexane1,3-diones as minor ones. Endocyclic enamino derivatives were synthesized in two steps through enol methyl ethers which reacted with amines. Endocyclic enamino derivatives of 2-(3-arylprop-2-enoyl) cyclohexane-1,3-diones containing an aryl group on the nitrogen atom readily underwent cyclization to 1,2,3,4,5,6,7,8-octa-hydroquinoline-4,5-dione derivatives.