4-methyl-2-(N-phenylamino)thiazole-5-carboxylic acid | 436094-60-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-methyl-2-(N-phenylamino)thiazole-5-carboxylic acid
• 英文别名: 4-Methyl-2-(phenylamino)-1,3-thiazole-5-carboxylic acid；2-anilino-4-methyl-1,3-thiazole-5-carboxylic acid
• CAS: 436094-60-9
• 化学式: C₁₁H₁₀N₂O₂S
• mdl: MFCD03011568
• 分子量: 234.279
• InChiKey: LNBUJXLOYNNILV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  90.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4,4-二氟-3-甲基-3-丁烯-1-基甲烷磺酸酯 、 4-methyl-2-(N-phenylamino)thiazole-5-carboxylic acid 在 碳酸氢钠 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 5.0h， 以53%的产率得到4,4-difluoro-3-methyl-3-butenyl 4-methyl-2-(N-phenylamino)thiazole-5-carboxylate
  参考文献：
  名称：

  DIFLUOROALKENE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE SAME, AND INTERMEDIATE THEREFOR

  摘要：

  公开号：

  EP1439169B1
• 作为产物：
  描述：

  乙基2-苯胺基-4-甲基-1,3-噻唑-5-羧酸酯 在 sodium hydroxide 、 乙醇 、 水 、 溶剂黄146 作用下， 以 水 为溶剂， 反应 15.0h， 以48%的产率得到4-methyl-2-(N-phenylamino)thiazole-5-carboxylic acid
  参考文献：
  名称：

  DIFLUOROALKENE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE SAME, AND INTERMEDIATE THEREFOR

  摘要：

  公开号：

  EP1439169B1

文献信息

• Difluoroalkene derivative, pest control agent containing the same, and intermediate therefor
  申请人：——

  公开号：US20040248872A1

  公开（公告）日：2004-12-09

  A difluoroalkene derivative which is sufficiently effective in controlling various pests even when used in a small dose and is highly safe for crops, natural enemies to the pests, and animals; and an intermediate for the derivative. The difluoroalkene derivative is represented by the general formula: [I] wherein L 1 and L 2 are the same or different and each represents oxygen or sulfur; n is an integer of 2 to 8; and Q represents a 5- to 12-membered heterocyclic group having any desired heteroatom selected among nitrogen, oxygen, and sulfur. 1

  一种二氟烯衍生物，即使使用小剂量也足以有效控制各种害虫，并且对作物，害虫的天敌和动物非常安全；以及该衍生物的中间体。该二氟烯衍生物由通式表示：[I]其中L1和L2相同或不同，每个代表氧或硫；n为2至8的整数；Q表示任何所需杂原子在氮、氧和硫之间选择的5-至12成员杂环基团。
• 5-Carboxamido Substituted Thiazole Derivatives that Interact With Ion Channels, In Particular With Ion Channels From the Kv Family
  申请人：Blom Petra

  公开号：US20080125432A1

  公开（公告）日：2008-05-29

  The present invention relates to compounds that interact with ion channels. In particular, the invention relates to compounds having the structural Formula having the structural Formula I, II, III or IV, stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or a pharmaceutically acceptable salt and/or solvate thereof, wherein X, Y 1 , Y 2 , R 1 , n, R 3 , R 8 , R 9 , R 10 , L 1 , L 2 , Ar 1 and Ar 2 are defined in claim 1 . The invention also relates to methods for preparing said compounds, to pharmaceutical compositions comprising said compounds, and to the use of said compounds in methods for treatment of the human and animal body.
• US7273878B2
  申请人：——

  公开号：US7273878B2

  公开（公告）日：2007-09-25