(1S,2R)-1-phenyl-1,2-cyclopropanedicarboxylic anhydride | 148261-93-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: (1S,2R)-1-phenyl-1,2-cyclopropanedicarboxylic anhydride
• 英文别名: (1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexane-2,4-dione
• CAS: 148261-93-2
• 化学式: C₁₁H₈O₃
• 分子量: 188.183
• InChiKey: VRVFLPPXIRCEOE-GZMMTYOYSA-N

物化性质

• 沸点：
  366.9±31.0 °C(Predicted)
• 密度：
  1.442±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1S,2R)-1-phenyl-1,2-cyclopropanedicarboxylic anhydride 在 氨 作用下， 生成 (1S,2R)-(-)-1-phenyl-1,2-cyclopropanedicarboximide
  参考文献：
  名称：

  Chiroptical properties of 1,2-cyclopropanedicarboxylic anhydrides and imides. The cyclopropane ring contribution to the Cotton effect

  摘要：

  Several optically active 1,2-cyclopropanedicarboxylic anhydrides and imides were prepared and their chiroptical spectra studied. Despite the strained bicyclic skeleton of these compounds, their CD spectra show an unusual solvent dependence. This phenomenon can be explained in terms of the cyclopropane ring contribution to the Cotton effect. A deviation of the skeleton and the anhydride or imide group from the local C(s) symmetry, shown by MNDO calculations, causes formation of an inherently chiral chromophore constituted by the three-membered ring and neighboring carbonyls. This kind of chromophore is responsible for the observed strong Cotton effects.

  DOI：

  10.1021/jo00064a034
• 作为产物：
  描述：

  (1S,2R)-1-phenyl-1,2-cyclopropanedicarboxylic acid 在 乙酰氯 作用下， 生成 (1S,2R)-1-phenyl-1,2-cyclopropanedicarboxylic anhydride
  参考文献：
  名称：

  Chiroptical properties of 1,2-cyclopropanedicarboxylic anhydrides and imides. The cyclopropane ring contribution to the Cotton effect

  摘要：

  Several optically active 1,2-cyclopropanedicarboxylic anhydrides and imides were prepared and their chiroptical spectra studied. Despite the strained bicyclic skeleton of these compounds, their CD spectra show an unusual solvent dependence. This phenomenon can be explained in terms of the cyclopropane ring contribution to the Cotton effect. A deviation of the skeleton and the anhydride or imide group from the local C(s) symmetry, shown by MNDO calculations, causes formation of an inherently chiral chromophore constituted by the three-membered ring and neighboring carbonyls. This kind of chromophore is responsible for the observed strong Cotton effects.

  DOI：

  10.1021/jo00064a034