2,3-O-Isopropyliden-L-erythrose | 77398-78-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,3-O-Isopropyliden-L-erythrose
• 英文别名: (3aR,6aR)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol；(3aR,4S,6aR)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-ol
• CAS: 77398-78-8
• 化学式: C₇H₁₂O₄
• 分子量: 160.17
• InChiKey: MBZCXOZTJSRAOQ-PBXRRBTRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  monomethylbistetrahydropyranylsawaranin 生成 2,3-O-Isopropyliden-L-erythrose
  参考文献：
  名称：

  HASEGAWA, SHINICHI;HIROSE, YOSHIYUKI;ERDTMAN, HOLGER, PHYTOCHEMISTRY, 27,(1988) N 8, C. 2703-2707

  摘要：

  DOI：

文献信息

• A Formal Synthesis of the C1−C9 Fragment of Amphidinolide C Employing the Tamaru Reaction
  作者：Mahesh P. Paudyal、Nigam P. Rath、Christopher D. Spilling

  DOI：10.1021/ol100959a

  日期：2010.7.2

  Homoallylation of aldehydes with isoprene and triethylborane catalyzed by Ni(acac)2 gave hydroxyalkenes in good yield with excellent regio- and stereoselectivity. Cross metathesis of the hydroxyalkenes with methyl acrylate using second-generation Grubbs catalyst and copper(I) iodide afforded α,β-unsaturated esters, which underwent cyclization in the presence of DBU to produce tetrahydrofurans with

  在Ni(acac) 2催化下，醛与异戊二烯和三乙基硼烷的均烯丙基化得到羟基烯烃，收率良好，具有出色的区域选择性和立体选择性。使用第二代 Grubbs 催化剂和碘化铜 (I) 将羟基烯烃与丙烯酸甲酯交叉复分解，得到 α,β-不饱和酯，在 DBU 存在下进行环化，生成具有正确 C1-C9 片段相对构型的四氢呋喃amphidinolides C、C2 和 F。
• Application of Oxidative Desymmetrization of meso-Tetrahydrofurans: Syntheses of Functionalized Chiral Building Blocks and of (-)-Alloyohimbane
  作者：Tsutomu Katsuki、Akio Miyafuji、Katsuji Ito

  DOI：10.3987/com-99-s20

  日期：——
• HASEGAWA, SHINICHI;HIROSE, YOSHIYUKI;ERDTMAN, HOLGER, PHYTOCHEMISTRY, 27,(1988) N 8, C. 2703-2707
  作者：HASEGAWA, SHINICHI、HIROSE, YOSHIYUKI、ERDTMAN, HOLGER

  DOI：——

  日期：——
• [EN] NOVOBIOCIN ANALOGUES AND TREATMENT OF POLYCYSTIC KIDNEY DISEASE<br/>[FR] ANALOGUES DE NOVOBIOCINE ET TRAITEMENT D'UNE MALADIE POLYKYSTIQUE DES REINS
  申请人：UNIV KANSAS

  公开号：WO2011041593A1

  公开（公告）日：2011-04-07

  Novobiocin analogues are useful in methods of treating, inhibiting, and/or preventing cyst formation in autosomal dominant polycystic kidney disease (ADPKD) in a subject. The disclosure provides methods of treating ADPKD comprising administering a therapeutically effective amount of a coumarin-3-carboxamide novobiocin analogue. Accordingly, the method can include administering a novobiocin analogue in a therapeutically effective amount for reducing levels of mTOR pathway phosphoproteins P-mTOR, P-Akt and P-S6K, or combinations thereof. Further, the method can include administering a novobiocin analogue in a therapeutically effective amount for reducing levels of Hsp-90 client proteins CFTR, ErbB2, c-Raf and Cdk4, or combinations thereof.