2,4,6-tri-O-benzoyl-3-O-propargyl-α-D-galactopyranosyl trichloroacetimidate | 1196990-41-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,4,6-tri-O-benzoyl-3-O-propargyl-α-D-galactopyranosyl trichloroacetimidate
• CAS: 1196990-41-6
• 化学式: C₃₂H₂₆Cl₃NO₉
• 分子量: 674.919
• InChiKey: RIBYDMIJCAQESH-OFBRLNSMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  45.0
• 可旋转键数：
  10.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  130.44
• 氢给体数：
  1.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  2,4,6-tri-O-benzoyl-3-O-propargyl-α-D-galactopyranosyl trichloroacetimidate 、 S-(11-hydroxy-undecyl) thioacetate 在 三氟甲磺酸三甲基硅酯 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 以95%的产率得到11-thioacetylundecyl 2,4,6-tri-O-benzoyl-3-O-propargyl-β-D-galactopyranoside
  参考文献：
  名称：

  Synthesis of Neu5Ac-Gal-functionalized gold glyconanoparticles

  摘要：

  Neu5Ac-Gal-containing neoglycoside 1 was convergently synthesized through Cu(I)-catalyzed 1,3-dipolar cycloaddition of methyl (6-azidohexyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-O-alpha-D-glycero-D-galacto-2-nonulopyranosyl)uronate and 11-thioacetylundecyl 2,4,6-tri-O-benzoyl-3-O-propargyl-beta-D-galactopyranoside. The stable and water-soluble gold glyconanoparticle 2 (d = 3.4 nm) has been successfully prepared from neoglycoside 1 and characterized by NMR, IR, and TEM techniques. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2009.06.039
• 作为产物：
  描述：

  、 三氯乙腈 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以594 mg的产率得到2,4,6-tri-O-benzoyl-3-O-propargyl-α-D-galactopyranosyl trichloroacetimidate
  参考文献：
  名称：

  Synthesis of Neu5Ac-Gal-functionalized gold glyconanoparticles

  摘要：

  Neu5Ac-Gal-containing neoglycoside 1 was convergently synthesized through Cu(I)-catalyzed 1,3-dipolar cycloaddition of methyl (6-azidohexyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-O-alpha-D-glycero-D-galacto-2-nonulopyranosyl)uronate and 11-thioacetylundecyl 2,4,6-tri-O-benzoyl-3-O-propargyl-beta-D-galactopyranoside. The stable and water-soluble gold glyconanoparticle 2 (d = 3.4 nm) has been successfully prepared from neoglycoside 1 and characterized by NMR, IR, and TEM techniques. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2009.06.039