2-amino-6-(4-bromophenyl)-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one | 1417520-93-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-amino-6-(4-bromophenyl)-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one
• 英文别名: 2-Amino-6-(4-bromophenyl)-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one
• CAS: 1417520-93-4
• 化学式: C₁₂H₉BrN₄O
• 分子量: 305.134
• InChiKey: GIJGQNKQBVHYAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.3
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-甲基哌嗪 、 2-amino-6-(4-bromophenyl)-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one 在 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 6-(4-bromophenyl)-4-(4-methylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
  参考文献：
  名称：

  Synthesis and evaluation of novel ligands for the histamine H4 receptor based on a pyrrolo[2,3-d]pyrimidine scaffold

  摘要：

  Starting from a known H4R ligand based on a pyrimidine skeleton, a series of novel analogues based on a pyrrolo[2,3-d]pyrimidine scaffold have been prepared. Whereas the original pyrimidine congener shows good affinity at hH(4)R (K-i = 0.5 mu M), its lacks selectivity with a K-i value for the hH(3)R of 1 mu M. Within the newly synthesized pyrrolo[2,3-d]pyrimidines, several congeners show K-i values of less than 1 mu M at the hH(4)R and show a much improved selectivity profile. Therefore, these series represent an interesting starting point for the discovery of novel hH(4)R ligands. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.10.139
• 作为产物：
  描述：

  2,4'-二溴苯乙酮 、 2,4-二氨基-6-羟基嘧啶 在 三乙胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以72%的产率得到2-amino-6-(4-bromophenyl)-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one
  参考文献：
  名称：

  New class of 8-aryl-7-deazaguanine cell permeable fluorescent probes

  摘要：

  A one step synthesis of fluorescent 8-aryl-(7-deazaguanines) has been accomplished. Probes exhibit blue to green high quantum yield fluorescence in a variety of organic and aqueous solutions, high extinction coefficients, and large Stokes shifts often above 100 nm. The probes are highly cell permeable, and exhibit stable bright fluorescence once intracellular; therefore are suited to the design of biosensors. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.08.054

文献信息

• New class of 8-aryl-7-deazaguanine cell permeable fluorescent probes
  作者：Ilirian Dhimitruka、Timothy D. Eubank、Amy C. Gross、Valery V. Khramtsov

  DOI：10.1016/j.bmcl.2015.08.054

  日期：2015.10

  A one step synthesis of fluorescent 8-aryl-(7-deazaguanines) has been accomplished. Probes exhibit blue to green high quantum yield fluorescence in a variety of organic and aqueous solutions, high extinction coefficients, and large Stokes shifts often above 100 nm. The probes are highly cell permeable, and exhibit stable bright fluorescence once intracellular; therefore are suited to the design of biosensors. (C) 2015 Elsevier Ltd. All rights reserved.
• Synthesis and evaluation of novel ligands for the histamine H4 receptor based on a pyrrolo[2,3-d]pyrimidine scaffold
  作者：Ling-Jie Gao、J. Stephan Schwed、Lilia Weizel、Steven De Jonghe、Holger Stark、Piet Herdewijn

  DOI：10.1016/j.bmcl.2012.10.139

  日期：2013.1

  Starting from a known H4R ligand based on a pyrimidine skeleton, a series of novel analogues based on a pyrrolo[2,3-d]pyrimidine scaffold have been prepared. Whereas the original pyrimidine congener shows good affinity at hH(4)R (K-i = 0.5 mu M), its lacks selectivity with a K-i value for the hH(3)R of 1 mu M. Within the newly synthesized pyrrolo[2,3-d]pyrimidines, several congeners show K-i values of less than 1 mu M at the hH(4)R and show a much improved selectivity profile. Therefore, these series represent an interesting starting point for the discovery of novel hH(4)R ligands. (C) 2012 Elsevier Ltd. All rights reserved.