(2-Mercaptomethyl-phenyl)-acetic acid | 913394-35-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-Mercaptomethyl-phenyl)-acetic acid
• 英文别名: 2-[2-(Sulfanylmethyl)phenyl]acetic acid；2-[2-(sulfanylmethyl)phenyl]acetic acid
• CAS: 913394-35-1
• 化学式: C₉H₁₀O₂S
• mdl: MFCD20657374
• 分子量: 182.243
• InChiKey: IIXXGGLRLXQIID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  38.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-Mercaptomethyl-phenyl)-acetic acid 在 三甲基铝 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 16.0h， 生成 Isothiochroman-3-one
  参考文献：
  名称：

  Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors

  摘要：

  Racemic derivatives of 3-amino-2-tetralone were synthesised and evaluated for their ability to inhibit metallo-aminopeptidase activities. New compounds substituted in position 2 by methyl ketone, substituted oximes or hydroxamic acids as well as heterocyclic derivatives were evaluated against representative members of zinc-dependent aminopeptidases: leucine aminopeptidase (E.C. 3.4.11.1), aminopeptidase-N(E.C. 3.4.11.2), Aeronumas proteolytica aminopeptidase (E.C. 3.4.11.10), and the aminopeptidase activity of leukotriene A(4) hydrolase (E.C. 3.3.2.6). Several compounds showed K-i values in the low micromolar range against the 'one-zinc' aminopeptidases, while most of them were rather poor inhibitors of the 'two-zinc' enzymes. This interesting selectivity profile may guide the design of new, specific inhibitors of target mammalian aminopeptidases with one active site zinc. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.06.050
• 作为产物：
  描述：

  甜菜安 在 sodium hydroxide 作用下， 以 水 、 丙酮 为溶剂， 反应 2.5h， 生成 (2-Mercaptomethyl-phenyl)-acetic acid
  参考文献：
  名称：

  Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors

  摘要：

  Racemic derivatives of 3-amino-2-tetralone were synthesised and evaluated for their ability to inhibit metallo-aminopeptidase activities. New compounds substituted in position 2 by methyl ketone, substituted oximes or hydroxamic acids as well as heterocyclic derivatives were evaluated against representative members of zinc-dependent aminopeptidases: leucine aminopeptidase (E.C. 3.4.11.1), aminopeptidase-N(E.C. 3.4.11.2), Aeronumas proteolytica aminopeptidase (E.C. 3.4.11.10), and the aminopeptidase activity of leukotriene A(4) hydrolase (E.C. 3.3.2.6). Several compounds showed K-i values in the low micromolar range against the 'one-zinc' aminopeptidases, while most of them were rather poor inhibitors of the 'two-zinc' enzymes. This interesting selectivity profile may guide the design of new, specific inhibitors of target mammalian aminopeptidases with one active site zinc. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.06.050

文献信息

• PHOTO-CURING MATERIAL MANUFACTURING METHOD, AND PHOTO-CURING MATERIAL AND ARTICLE
  申请人：Asahi Glass Company Limited

  公开号：EP2360195A1

  公开（公告）日：2011-08-24

  To provide a photocurable material which can form a cured product having a high transparency and a high refractive index, a process for producing the material easily, and an article having a high transparency and a high refractive index. The photocurable material is obtained by a production process comprising (i) a step of reacting a polymerizable component (A) comprised of at least one type of a compound (a) having a (meth)acryloyloxy group, and a compound (B) having a mercapto group and a carboxy group to obtain a surface modifier (C) which has the carboxy group derived from the compound (B) at a terminal, (ii) a step of modifying the surface of inorganic fine particles (D) with the surface modifier (C) to obtain surface-modified inorganic fine particles (E), and (iii) a step of obtaining a photocurable material which contains the surface-modified inorganic fine particles (E), a polymerizable component (F) comprised of at least one type of a compound (f) having a (meth)acryloyloxy group, and a photopolymerization initiator (G).

  提供一种可形成具有高透明度和高折射率的固化物的光固化材料、一种易于生产该材料的工艺以及一种具有高透明度和高折射率的制品。 这种光固化材料是通过以下生产工艺获得的： (i) 第一步：使由至少一种具有(甲基)丙烯酰氧基的化合物(a)和具有巯基和羧基的化合物(B)组成的可聚合组分(A)与表面改性剂(C)反应，表面改性剂(C)的末端具有来自化合物(B)的羧基、(ii) 用表面改性剂（C）改性无机微粒（D）的表面，以获得表面改性无机微粒 （E），以及 (iii) 获得光固化材料的步骤，该材料包含表面改性无机微粒（E）、由至少一种具有 （甲基）丙烯酰氧基的化合物（f）和光聚合引发剂（G）组成的可聚合组分（F）。
• PROCESS FOR PRODUCING PHOTOCURABLE MATERIAL, PHOTOCURABLE MATERIAL AND ARTICLE
  申请人：NOMOTO Hideo

  公开号：US20110237703A1

  公开（公告）日：2011-09-29

  To provide a photocurable material which can form a cured product having a high transparency and a high refractive index, a process for producing the material easily, and an article having a high transparency and a high refractive index. The photocurable material is obtained by a production process comprising (i) a step of reacting a polymerizable component (A) comprised of at least one type of a compound (a) having a (meth)acryloyloxy group, and a compound (B) having a mercapto group and a carboxy group to obtain a surface modifier (C) which has the carboxy group derived from the compound (B) at a terminal, (ii) a step of modifying the surface of inorganic fine particles (D) with the surface modifier (C) to obtain surface-modified inorganic fine particles (E), and (iii) a step of obtaining a photocurable material which contains the surface-modified inorganic fine particles (E), a polymerizable component (F) comprised of at least one type of a compound (f) having a (meth)acryloyloxy group, and a photopolymerization initiator (G).
• US8207242B2
  申请人：——

  公开号：US8207242B2

  公开（公告）日：2012-06-26