4,5,6,7-tetrahydro-2-indanol | 59078-17-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4,5,6,7-tetrahydro-2-indanol
• 英文别名: octahydro-1H-inden-2-ol；2,3,3a,4,5,6,7,7a-octahydro-1H-inden-2-ol
• CAS: 59078-17-0
• 化学式: C₉H₁₆O
• 分子量: 140.225
• InChiKey: FNTAZLZSKBIIIW-UHFFFAOYSA-N

物化性质

• 沸点：
  229.0±8.0 °C(Predicted)
• 密度：
  1.018±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  二氯甲烷 、 4,5,6,7-tetrahydro-2-indanol 在 正丁基锂 、 氨 、 sodium 作用下， 生成 exo-8-hydroxytricyclo<4.3.1.0^1,6>decane
  参考文献：
  名称：

  SN2 substitution with inversion at a cyclopropyl carbon atom: formation of 9-oxatetracyclo[6.2.1.01,6.06,10]undecane

  摘要：

  DOI：

  10.1021/ja00376a037
• 作为产物：
  描述：

  2-茚酮 以85%的产率得到
  参考文献：
  名称：

  CLARK D. A.; FUCHS P. L., J. AMER. CHEM. SOC., 1979, 101, NO 13, 3567-3576

  摘要：

  DOI：

文献信息

• Novel alkaloids
  申请人：University of Vermont

  公开号：US04935509A1

  公开（公告）日：1990-06-19

  Cycloalkyl and aromatic vinblastine and vincristine derivatives useful as anti-tumor agents.

  环烷基和芳香基长春碱和长春花碱衍生物，可用作抗肿瘤剂。
• KRAWCZYK, ANDRZEJ R.;JONES, J. BRYAN, J. ORG. CHEM., 54,(1989) N, C. 1795-1801
  作者：KRAWCZYK, ANDRZEJ R.、JONES, J. BRYAN

  DOI：——

  日期：——
• MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
  申请人：RQx Pharmaceuticals, Inc.

  公开号：US20210198316A9

  公开（公告）日：2021-07-01

  Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
• [EN] [6+5] FUSED BICYCLES AS A THROMBIN ANTAGONIST, PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE BICYCLES<br/>[FR] BICYCLES FUSIONNÉS [6+5] EN TANT QU'ANTAGONISTES DE LA THROMBINE, PROCÉDÉ DE PRÉPARATION DE CEUX-CI ET COMPOSITIONS PHARMACEUTIQUES CONTENANT LES BICYCLES
  申请人：KOREA RES INST CHEM TECH

  公开号：WO2011162562A2

  公开（公告）日：2011-12-29

  The present invention relates to the new [6+5] fused bicycle derivatives, pharmaceutically acceptable salts or isomers thereof, processes for preparing the same, and pharmaceutical compositions comprising the same. The [6+5] fused bicycle derivatives can antagonize the thrombin receptor and thus may be effectively used for the treatment and prevention of thrombus, platelet aggregation, atherosclerosis, restenosis, blood coagulation, hypertension, arrhythmia, angina pectoris, heart failure, inflammation and cancer when used alone or with other cardiovascular agents.
• [EN] INHIBITORS OF CENTRAL NERVOUS SYSTEM VASOACTIVE INHIBITORY PEPTIDE RECEPTOR 2<br/>[FR] INHIBITEURS DU RÉCEPTEUR 2 DE PEPTIDE INHIBITEUR VASO-ACTIF DU SYSTÈME NERVEUX CENTRAL
  申请人：UNIV COLUMBIA

  公开号：WO2014075096A1

  公开（公告）日：2014-05-15

  The present invention relates to compounds that inhibit VIPR2 in the CNS, pharmaceutical compositions comprising said compounds, and methods of using such compounds and compositions in the treatment of a CNS disorder such as a behavioral disorder, including but not limited to schizophrenia.