1-Isopropylamino-4,4-dimethyl-pentan-3-one | 130539-92-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Isopropylamino-4,4-dimethyl-pentan-3-one
• 英文别名: 4,4-Dimethyl-1-(propan-2-ylamino)pentan-3-one
• CAS: 130539-92-3
• 化学式: C₁₀H₂₁NO
• 分子量: 171.283
• InChiKey: FANQFFMFYNYAPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N,N-bis(ethoxymethyl)-iso-propylamine 、 (1-叔丁基乙烯氧基)三甲基硅烷 生成 1-Isopropylamino-4,4-dimethyl-pentan-3-one
  参考文献：
  名称：

  EARLE, MARTYN J.;FAIRHURST, ROBIN A.;HEANEY, HARRY;PAPAGEORGIOU, GEORGE;W+, TETRAHEDRON LETT., 31,(1990) N9, C. 4229-4232

  摘要：

  DOI：

文献信息

• A new route to secondary amines from bis-(alkoxymethyl)-alkylamines - the activation of an aminomethyl group and protection of the product by the same functional group
  作者：Martyn J. Earle、Robin A. Fairhurst、Harry Heaney、George Papageorgiou、Robert F. Wilkins

  DOI：10.1016/s0040-4039(00)97589-0

  日期：1990.1

  variety of acidic reagents affords good yields of N-alkoxymethyl-N-alkylmethyleneiminium salts which react with trimethylsilyl enol ethers, and nucleophilic aromatic substrates to form protected secondary amines or tertiary amines by domino reactions; silyl ketene acetals afford tertiary amines only.

  的治疗N，N- -双用各种酸性试剂，得到良好的产率的（烷氧基）烷基胺Ñ -alkoxymethyl- Ñ -alkylmethyleneiminium盐，其与三甲基甲硅烷烯醇醚反应，亲核芳族底物，通过多米诺形式保护的仲胺或叔胺反应; 甲硅烷基乙烯酮缩醛仅提供叔胺。
• COMPOUNDS AND METHODS FOR MODULATING FRATAXIN EXPRESSION
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20170281643A1

  公开（公告）日：2017-10-05

  The present technology relates to compositions and methods for modulating expression of genes, which include a target oligonucleotide sequence, such as repeats of a particular oligonucleotide sequence containing 3 to 10 nucleotides. In particular aspects, the present technology relates to agents having a formula A-L-B, wherein -L- is a linker; A- is a Brd4 binding moiety; and -B is a nucleic acid binding moiety, such as a polyamide or complementary oligonucleotide, that specifically binds to the target oligonucleotide sequence.

  本技术涉及用于调节基因表达的组合物和方法，其中包括一个目标寡核苷酸序列，例如包含3到10个核苷酸的特定寡核苷酸序列的重复。在特定方面，本技术涉及具有A-L-B公式的试剂，其中-L-是连接剂；A-是Brd4结合基团；-B是核酸结合基团，例如聚酰胺或互补寡核苷酸，可特异性结合目标寡核苷酸序列。
• METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE
  申请人：Design Therapeutics, Inc.

  公开号：US20210228723A1

  公开（公告）日：2021-07-29

  The present disclosure relates to compounds and methods which may be useful for modulating the expression of fxn and treating diseases and conditions in which fxn plays an active role. The compound can be a transcription modulator molecule having a first terminus, a second terminus, and oligomeric backbone, wherein: a) the first terminus comprises a DNA-binding moiety capable of noncovalently binding to a nucleotide repeat sequence GAA; b) the second terminus comprises a protein-binding moiety binding to a regulatory molecule that modulates an expression of a gene comprising the nucleotide repeat sequence GAA; and c) the oligomeric backbone comprising a linker between the first terminus and the second terminus.