5-acetyl-4-chloro-2,6-dimethylpyrimidine | 26138-87-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-acetyl-4-chloro-2,6-dimethylpyrimidine
• 英文别名: 5-Acetyl-4-chlor-2,6-dimethyl-pyrimidin；1-(4-chloro-2,6-dimethyl-pyrimidin-5-yl)-ethanone；1-(4-Chloro-2,6-dimethylpyrimidin-5-yl)ethanone
• CAS: 26138-87-4
• 化学式: C₈H₉ClN₂O
• 分子量: 184.625
• InChiKey: KUTYKKVYWNBBFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  42.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-acetyl-4-chloro-2,6-dimethylpyrimidine 、 2-氨基苯硫醇 生成 2,4,5-trimethyl-benzo[b]pyrimido[5,4-f][1,4]thiazepine
  参考文献：
  名称：

  Wamhof,H.; Korte,F., Synthesis, 1972, p. 151 - 175

  摘要：

  DOI：
• 作为产物：
  描述：

  5-乙酰基-2,6-二甲基嘧啶-4(3H)-酮 在 三氯氧磷 作用下， 反应 0.75h， 以74%的产率得到5-acetyl-4-chloro-2,6-dimethylpyrimidine
  参考文献：
  名称：

  Kato, Tetsuzo; Sato, Masayuki; Wagai, Akihiro, Journal of Heterocyclic Chemistry, 1981, vol. 18, p. 603 - 606

  摘要：

  DOI：

文献信息

• HETEROARYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSTION FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH PI3 KINASES, CONTAINING SAME AS ACTIVE INGREDIENT
  申请人：KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

  公开号：US20180105527A1

  公开（公告）日：2018-04-19

  The present invention relates to a heteroaryl derivative or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition for preventing or treating diseases associated with PI3 kinases, containing the same as an active ingredient. The heteroaryl derivative according to the present invention has an excellent effect of selectively inhibiting PI3 kinases, thereby being useful in preventing or treating PI3 kinase diseases such as: cancers, autoimmune diseases, and respiratory diseases.

  本发明涉及一种杂环芳基衍生物或其药用可接受盐，以及其制备方法和包含其作为活性成分的用于预防或治疗与PI3激酶相关疾病的药物组合物。根据本发明的杂环芳基衍生物具有优异的选择性抑制PI3激酶的效果，因此在预防或治疗癌症、自身免疫疾病和呼吸道疾病等PI3激酶疾病方面具有用处。
• KATO TETSUZO; SATO MASAYUKI; WAGAI AKIHIRO, J. HETEROCYCL. CHEM., 1981, 18, NO 3, 603-606
  作者：KATO TETSUZO、 SATO MASAYUKI、 WAGAI AKIHIRO

  DOI：——

  日期：——
• Non Metal Tanning
  申请人：Reineking Claus

  公开号：US20130227799A1

  公开（公告）日：2013-09-05

  Tanned leather, skin or pelt is produced by non-metal tanning, comprising the step of tanning a bated hide, skin or pelt with a tanning agent (A), the tanning agent (A) being at least one compound of formula (I), R—NH—Y—SO 2 —Z  (I), wherein R signifies a radical of formula wherein Hal signifies fluorine or chlorine, X signifies N or CR1, Y signifies an aliphatic, araliphatic or aromatic hydrocarbonic bridge which may optionally be interrupted by a heteroatom or heteroatomic group, Z signifies vinyl, β-chloroethyl, β-phosphatoethyl or β-sulphatoethyl R1 signifies hydrogen or Cl, in a tanning bath, the tanning bath having a pH of from 6 to 10 at the beginning of tanning step.
• US8679196B2
  申请人：——

  公开号：US8679196B2

  公开（公告）日：2014-03-25
• Kato, Tetsuzo; Sato, Masayuki; Wagai, Akihiro, Journal of Heterocyclic Chemistry, 1981, vol. 18, p. 603 - 606
  作者：Kato, Tetsuzo、Sato, Masayuki、Wagai, Akihiro

  DOI：——

  日期：——