2-甲基-2-丙基2-亚甲基环丙烷羧酸酯 | 219788-08-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-甲基-2-丙基2-亚甲基环丙烷羧酸酯
• 英文名称: (+/-)-tert-butyl 2-methylene-cyclopropane-1-carboxylate
• 英文别名: Tert-butyl 2-methylidenecyclopropane-1-carboxylate
• CAS: 219788-08-6
• 化学式: C₉H₁₄O₂
• 分子量: 154.209
• InChiKey: SVWPWCXEYKAXSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-甲基-2-丙基2-亚甲基环丙烷羧酸酯 在 盐酸 、 dirhodium tetraacetate 、 sodium hydroxide 、 sodium azide 、 18-冠醚-6 、 potassium carbonate 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 102.5h， 生成 (+/-)-distal-1-aminospiro[2.2]pentane-1,4-dicarboxylic acid
  参考文献：
  名称：

  Spiro[2.2]pentane as a Dissymmetric Scaffold for Conformationally Constrained Analogues of Glutamic Acid:  Focus on Racemic 1-Aminospiro[2.2]pentyl-1,4-dicarboxylic Acids

  摘要：

  In search for novel conformationally constrained analogues of L-glutamic acid, a diastereodivergent synthesis of the four 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acid racernic pairs is reported along with their stereochemical assignment, conformational analysis, and preliminary biological evaluation as potential glutamate (ionotropic and metabotropic) ligands.

  DOI：

  10.1021/jo020138v
• 作为产物：
  描述：

  重氮基乙酸叔丁酯 在 dirhodium tetraacetate 、 potassium tert-butylate 作用下， 以 二氯甲烷 、 二甲基亚砜 为溶剂， 反应 96.83h， 生成 2-甲基-2-丙基2-亚甲基环丙烷羧酸酯
  参考文献：
  名称：

  Spiro[2.2]pentane as a Dissymmetric Scaffold for Conformationally Constrained Analogues of Glutamic Acid:  Focus on Racemic 1-Aminospiro[2.2]pentyl-1,4-dicarboxylic Acids

  摘要：

  In search for novel conformationally constrained analogues of L-glutamic acid, a diastereodivergent synthesis of the four 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acid racernic pairs is reported along with their stereochemical assignment, conformational analysis, and preliminary biological evaluation as potential glutamate (ionotropic and metabotropic) ligands.

  DOI：

  10.1021/jo020138v

文献信息

• Spiro[2.2]pentane as a Dissymmetric Scaffold for Conformationally Constrained Analogues of Glutamic Acid:  Focus on Racemic 1-Aminospiro[2.2]pentyl-1,4-dicarboxylic Acids
  作者：Roberto Pellicciari、Maura Marinozzi、Emidio Camaioni、Maria del Carmen Nùnez、Gabriele Costantino、Fabrizio Gasparini、Gianluca Giorgi、Antonio Macchiarulo、Natarajan Subramanian

  DOI：10.1021/jo020138v

  日期：2002.8.1

  In search for novel conformationally constrained analogues of L-glutamic acid, a diastereodivergent synthesis of the four 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acid racernic pairs is reported along with their stereochemical assignment, conformational analysis, and preliminary biological evaluation as potential glutamate (ionotropic and metabotropic) ligands.