1-(5-chloro-[2]thienyl)-3t-[2]furyl-propenone | 99866-56-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(5-chloro-[2]thienyl)-3t-[2]furyl-propenone
• 英文别名: 1-(5-Chlor-[2]thienyl)-3t-[2]furyl-propenon；(E)-1-(5-Chloro-thiophen-2-yl)-3-furan-2-yl-propenone；(E)-1-(5-chlorothiophen-2-yl)-3-(furan-2-yl)prop-2-en-1-one
• CAS: 99866-56-5
• 化学式: C₁₁H₇ClO₂S
• 分子量: 238.694
• InChiKey: SGICLQSFCAZZQE-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  糠醛 、 2-乙酰基-5-氯噻酚 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 生成 1-(5-chloro-[2]thienyl)-3t-[2]furyl-propenone
  参考文献：
  名称：

  Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities

  摘要：

  For the development of safer anti-inflammatory agents, simple aromatic compounds containing propenone moiety were prepared and evaluated for their dual COX/5-LOX inhibitory activities. Among the 17 prepared compounds, most of the compounds exhibited considerable COX/5-LOX inhibitory activities. Especially compound C-15 showed the most significant dual COX/5-LOX inhibitory activity. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.02.099

文献信息

• Buu-Hoi et al., Bulletin de la Societe Chimique de France, 1956, p. 1646,1648
  作者：Buu-Hoi et al.

  DOI：——

  日期：——
• Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities
  作者：Yurngdong Jahng、Long-Xuan Zhao、Yoon-Soo Moon、Arjun Basnet、Eun-kyung Kim、Hyeun Wook Chang、Hye Kyung Ju、Tae Cheon Jeong、Eung-Seok Lee

  DOI：10.1016/j.bmcl.2004.02.099

  日期：2004.5

  For the development of safer anti-inflammatory agents, simple aromatic compounds containing propenone moiety were prepared and evaluated for their dual COX/5-LOX inhibitory activities. Among the 17 prepared compounds, most of the compounds exhibited considerable COX/5-LOX inhibitory activities. Especially compound C-15 showed the most significant dual COX/5-LOX inhibitory activity. (C) 2004 Elsevier Ltd. All rights reserved.