2-ethyl-N-hydroxyhexanamide | 36369-08-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-ethyl-N-hydroxyhexanamide
• CAS: 36369-08-1
• 化学式: C₈H₁₇NO₂
• mdl: MFCD04067577
• 分子量: 159.228
• InChiKey: OHMSHECKDPWUIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-ethyl-N-hydroxyhexanamide 在 α,α,α-三联吡啶 、 iron(II) chloride 作用下， 以 二氯甲烷 、 1,2-二氯乙烷 、 正戊烷 为溶剂， 生成
  参考文献：
  名称：

  配体促进的铁催化氮烯转移通过芳胺的 N-酰胺化合成肼和三氮烷

  摘要：

  大体积烷基膦 (P t Bu 3 ) 可以将角色从参与者配体转换为旁观者配体，以促进 FeCl 2催化的芳胺与二恶唑酮的N酰胺化反应，从而高效且具有化学选择性地生成酰肼。新的配体促进的N -酰胺化方案提供了一种通过伯芳胺的双重或连续N -酰胺化来获得各种具有挑战性的三氮烷化合物的便捷方法。

  DOI：

  10.1002/anie.202312465
• 作为产物：
  描述：

  2-乙基己酰氯 在 盐酸羟胺 、 potassium carbonate 作用下， 以 水 、 乙酸乙酯 为溶剂， 生成 2-ethyl-N-hydroxyhexanamide
  参考文献：
  名称：

  配体促进的铁催化氮烯转移通过芳胺的 N-酰胺化合成肼和三氮烷

  摘要：

  大体积烷基膦 (P t Bu 3 ) 可以将角色从参与者配体转换为旁观者配体，以促进 FeCl 2催化的芳胺与二恶唑酮的N酰胺化反应，从而高效且具有化学选择性地生成酰肼。新的配体促进的N -酰胺化方案提供了一种通过伯芳胺的双重或连续N -酰胺化来获得各种具有挑战性的三氮烷化合物的便捷方法。

  DOI：

  10.1002/anie.202312465

文献信息

• Treatment of protein degradation disorders
  申请人：President and Fellows of Harvard College

  公开号：US10172905B1

  公开（公告）日：2019-01-08

  The invention relates to methods of treating protein degradation disorders, such cellular proliferative disorders (e.g., cancer) and protein deposition disorders (e.g., neurodegenerative disorders). The invention provides methods and pharmaceutical compositions for treating these diseases using aggresome inhibitors or combinations of aggresome inhibitors and proteasome inhibitors. The invention further relates to methods and pharmaceutical compositions for treating multiple myeloma. New HDAC/TDAC inhibitors and aggresome inhibitors are also provided as well as synthetic methodologies for preparing these compounds.

  本发明涉及治疗蛋白质降解紊乱的方法，如细胞增殖紊乱（如癌症）和蛋白质沉积紊乱（如神经退行性疾病）。本发明提供了使用侵袭酶体抑制剂或侵袭酶体抑制剂和蛋白酶体抑制剂组合治疗这些疾病的方法和药物组合物。本发明还涉及治疗多发性骨髓瘤的方法和药物组合物。本发明还提供了新的 HDAC/TDAC 抑制剂和侵袭体抑制剂以及制备这些化合物的合成方法。
• Carbonic anhydrase inhibitors. Inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with branched aliphatic/aromatic carboxylates and their derivatives
  作者：Fabrizio Carta、Alessio Innocenti、Rebecca A. Hall、Fritz A. Mühlschlegel、Andrea Scozzafava、Claudiu T. Supuran

  DOI：10.1016/j.bmcl.2011.02.057

  日期：2011.4

  The inhibition of the beta-carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic fungi Cryptococcus neoformans (Can2) and Candida albicans (Nce103) with a series of 25 branched aliphatic and aromatic carboxylates has been investigated. Human isoforms hCA I and II were also included in the study for comparison. Aliphatic carboxylates were generally millimolar hCA I and II inhibitors and low micromolar/submicromolar beta-CA inhibitors. Aromatic carboxylates were micromolar inhibitors of the four enzymes but some of them showed low nanomolar activity against the fungal pathogenic enzymes. 4-Hydroxy-and 4-methoxy-benzoate inhibited Can2 with K(I)s of 9.5-9.9 nM. The methyl esters, hydroxamates, hydrazides and carboxamides of some of these derivatives were also effective inhibitors of the alpha- and beta-CAs investigated here. (C) 2011 Elsevier Ltd. All rights reserved.
• N-ETHYL HYDROXAMIC ACID CHELANTS
  申请人：MONSANTO COMPANY

  公开号：EP0598747A1

  公开（公告）日：1994-06-01
• COMPOSITION AND METHOD FOR PREVENTING OR REDUCING LOW SPEED PRE-IGNITION IN SPARK-IGNITED INTERNAL COMBUSTION ENGINES
  申请人：Chevron Oronite Company LLC

  公开号：US20200017789A1

  公开（公告）日：2020-01-16

  Disclosed herein is a fuel composition having (1) greater than 50 wt % of a hydrocarbon fuel boiling in the gasoline or diesel range and (2) a minor amount of a low-speed pre-ignition (LSPI)-reducing additive having one or more of an amidine, or a beta-amino alkanol having the structure R 1 , R 2 , R 3 , and R 4 are each independently selected from hydrogen, aromatic ring, and a C 1 -C 20 alkyl group and R 5 is hydrogen or an alcohol having the structure —(CH)R 6 —OH. R 6 is hydrogen, a C 1 -C 10 alkyl group, or a C 1 -C 10 alkenyl group, or a salt thereof.
• US5174917A
  申请人：——

  公开号：US5174917A

  公开（公告）日：1992-12-29