m-nitrobenzyl allyl ether | 117401-73-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: m-nitrobenzyl allyl ether
• 英文别名: 1-Allyloxymethyl-3-nitrobenzene；1-nitro-3-(prop-2-enoxymethyl)benzene
• CAS: 117401-73-7
• 化学式: C₁₀H₁₁NO₃
• 分子量: 193.202
• InChiKey: NJRKXXSCGFSHSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  m-nitrobenzyl allyl ether 在 盐酸 、 lithium hydroxide 、 sodium periodate 、 四氧化锇 、 正丁基锂 、 sodium azide 、 N,N'-二环己基碳二亚胺 、 tin(ll) chloride 、 sodium nitrite 作用下， 以 甲醇 、 乙二醇二甲醚 、 乙醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 201.42h， 生成 N-<(6-m-azidobenzyloxy)-E,E-2,4-hexadienoamide>-L-tyrosyl-N,N'-di-Boc-spermine-N-α-N^G,N^G'-tri-Boc-L-arginine di-amide
  参考文献：
  名称：

  Synthesis of novel and photolabile philanthotoxin analogs: Glutamate receptor antagonists

  摘要：

  The synthetic methods for 27 novel and photolabile philanthotoxin analogs are described. Most analogs were synthesized by two general methods with modifications of these methods where necessary.

  DOI：

  10.1016/s0040-4020(01)81575-1
• 作为产物：
  描述：

  间硝基氯化苄 生成 m-nitrobenzyl allyl ether
  参考文献：
  名称：

  SIDA, TAKAFUMI;KUBOTA, JOSIKADZU;ITINOSEH, ISAO

  摘要：

  DOI：

文献信息

• Rhodium-Catalyzed Annulation of <i>N</i>-Acetoxyacetanilide with Substituted Alkynes: Conversion of Nitroarenes to Substituted Indoles
  作者：Jayanta Ghorai、Kuppan Ramachandran、Pazhamalai Anbarasan

  DOI：10.1021/acs.joc.1c01604

  日期：2021.11.5

  nitroarenes. The important features are the introduction of N-acetoxyacetamide as a new directing group, redox-neutral annulation, an additive-free approach, wide functional group tolerance, an intramolecular version, and a one-pot reaction of nitroarenes. The method was further extended to the synthesis of potent higher analogues of indole, viz., pyrrolo[3,2-f]indoles and dibenzo[a,c]carbazoles. In addition

  N-乙酰氧基乙酰苯胺的一般和有效的铑催化氧化还原中性环化，容易从硝基芳烃中获得，与炔烃已经完成，用于合成取代的吲哚衍生物。从各种取代的N-乙酰氧基乙酰苯胺和对称/不对称炔烃中获得了范围广泛的取代 2,3-二芳基吲哚，产率从良好到优异。所开发的方法成功地与N-乙酰氧基乙酰苯胺的合成相结合，用于从硝基芳烃中有效地一锅法合成吲哚。重要的特点是引入了N-乙酰氧基乙酰胺作为新的导向基团，氧化还原中性环化，无添加剂方法，广泛的官能团耐受性，分子内形式和硝基芳烃的一锅反应。该方法进一步扩展到合成有效的高级吲哚类似物，即。、吡咯并[3,2- f ]吲哚和二苯并[ a , c ]咔唑。此外，基于潜在芳基-Rh中间体的分离和化学计量研究，提出了一种合理的机制。
• Highly Efficient Stereoselective Catalytic C(sp³)H Insertions with Donor Rhodium Carbenoids Generated from Cyclopropenes
  作者：Alexis Archambeau、Frédéric Miege、Christophe Meyer、Janine Cossy

  DOI：10.1002/anie.201205913

  日期：2012.11.12

  Rings of five and six: Donor alkenyl rhodium carbenoids generated from 3,3‐dimethylcyclopropenylcarbinols exhibit high reactivity in intramolecular CH insertions. The reactions proceed under remarkably mild conditions, tolerate the presence of the free hydroxy group, and afford an efficient and stereoselective access to a variety of functionalized carbocycles and oxygen heterocycles.

  的五和六环：从3,3- dimethylcyclopropenylcarbinols产生供体链烯基铑卡宾表现出在分子内1C高反应性 ħ插入。反应在非常温和的条件下进行，可以容忍游离羟基的存在，并且可以高效，立体选择性地进入各种功能化的碳环和氧杂环。
• OXYGEN LINKED PYRIMIDINE DERIVATIVES
  申请人：Blanchard Stephanie

  公开号：US20120196855A1

  公开（公告）日：2012-08-02

  The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to oxygen linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other disorders or conditions related to or associated with kinases.

  本发明涉及嘧啶化合物，其作为抗增殖剂具有用处。更具体地说，本发明涉及氧连接和取代的嘧啶化合物，其制备方法，含有这些化合物的制药组合物以及这些化合物在治疗增殖性疾病方面的用途。这些化合物可用作治疗许多增殖性疾病，包括肿瘤和癌症以及与激酶相关或相关的其他疾病或病况的药物。
• HETEROALKYL LINKED PYRIMIDINE DERIVATIVES
  申请人：Blanchard Stephanie

  公开号：US20090258886A1

  公开（公告）日：2009-10-15

  The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to heteroalkyl linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other conditions or disorders associated with kinases.

  本发明涉及用作抗增殖剂的嘧啶化合物。更具体地说，本发明涉及杂原子烷基连接和取代的嘧啶化合物，其制备方法，含有这些化合物的制药组合物以及在治疗增殖性疾病中使用这些化合物的用途。这些化合物可能作为药物对许多增殖性疾病，包括肿瘤和癌症以及与激酶相关的其他疾病或疾病的治疗有用。
• Oxygen linked pyrimidine derivatives
  申请人：CTI BIOPHARMA CORP.

  公开号：US11135227B2

  公开（公告）日：2021-10-05

  The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to oxygen linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other disorders or conditions related to or associated with kinases.

  本发明涉及可用作抗增殖剂的嘧啶化合物。 更具体地说，本发明涉及氧连接和取代的嘧啶化合物、其制备方法、含有这些化合物的药物组合物以及这些化合物在治疗增殖性疾病中的用途。 这些化合物可用作治疗多种增殖性疾病的药物，包括肿瘤和癌症以及与激酶有关或相关的其他疾病或病症。