1-(5,5-Dimethyl-4,6-dioxa-spiro[2.5]oct-7-yl)-cyclopropanol | 868630-83-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(5,5-Dimethyl-4,6-dioxa-spiro[2.5]oct-7-yl)-cyclopropanol
• 英文别名: 1-(5,5-Dimethyl-4,6-dioxaspiro[2.5]octan-7-yl)cyclopropan-1-ol
• CAS: 868630-83-5
• 化学式: C₁₁H₁₈O₃
• 分子量: 198.262
• InChiKey: NIMGMMDBUOXRBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(5,5-Dimethyl-4,6-dioxa-spiro[2.5]oct-7-yl)-cyclopropanol 在 三乙胺 、 magnesium bromide 作用下， 以 乙醚 、 氯仿 为溶剂， 反应 6.0h， 生成 7-(1-Bromomethyl-vinyl)-5,5-dimethyl-4,6-dioxa-spiro[2.5]octane
  参考文献：
  名称：

  Differentiation between the ethoxycarbonyl groups in diethyl malate via their titanium-catalyzed reductive cyclopropanation with ethylmagnesium bromide and subsequent site-selective three-carbon ring cleavage

  摘要：

  Ethoxycarbonyl groups in O-THP protected racemic diethyl malate I were differentiated by their reductive cyclopropanation with ethylmagnesium bromide in the presence of titanium(IV) isopropoxide and subsequent site-selective C1-C2, C2-C3 or both C1-C2 and C1-C3 ring cleavage of the cyclopropyl groups of the resulting bis-cyclopropanol 2. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.08.076
• 作为产物：
  描述：

  1-[2-(1-hydroxycyclopropyl)-2-(oxan-2-yloxy)ethyl]cyclopropan-1-ol 在 4-甲基苯磺酸吡啶 、 copper(II) sulfate 作用下， 以 甲醇 为溶剂， 生成 1-(5,5-Dimethyl-4,6-dioxa-spiro[2.5]oct-7-yl)-cyclopropanol
  参考文献：
  名称：

  Differentiation between the ethoxycarbonyl groups in diethyl malate via their titanium-catalyzed reductive cyclopropanation with ethylmagnesium bromide and subsequent site-selective three-carbon ring cleavage

  摘要：

  Ethoxycarbonyl groups in O-THP protected racemic diethyl malate I were differentiated by their reductive cyclopropanation with ethylmagnesium bromide in the presence of titanium(IV) isopropoxide and subsequent site-selective C1-C2, C2-C3 or both C1-C2 and C1-C3 ring cleavage of the cyclopropyl groups of the resulting bis-cyclopropanol 2. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.08.076

文献信息

• Simple access to β-trifluoromethyl-substituted ketones via copper-catalyzed ring-opening trifluoromethylation of substituted cyclopropanols
  作者：Dzmitry G. Kananovich、Yulia A. Konik、Dzmitry M. Zubrytski、Ivar Järving、Margus Lopp

  DOI：10.1039/c5cc02386f

  日期：——

  A variety of β-trifluoromethyl ketones have been easily prepared by CuCl-catalyzed ring-opening trifluoromethylation of cyclopropanols with Togni reagent.

  一种多样的β-三氟甲基酮已经通过CuCl催化的环丙醇与Togni试剂的环开三氟甲基化反应轻松制备。
• Preparation of isopropylidene acetals from butane-1,2,4-triol and its cyclopropane congeners
  作者：Konstantin N. Prokhorevich、Andrei V. Bekish

  DOI：10.1016/j.tetlet.2010.05.126

  日期：2010.8

  Features of isopropylidene acetal synthesis from butane-1,2,4-triol and its cyclopropane congeners were studied. Procedures for the preparation and purification of the respective acetonides have been developed.

  研究了由1,2,4-丁三醇及其环丙烷同源物合成异亚丙基缩醛的特性。已经开发了制备和纯化各个丙酮化物的方法。
• Differentiation between the ethoxycarbonyl groups in diethyl malate via their titanium-catalyzed reductive cyclopropanation with ethylmagnesium bromide and subsequent site-selective three-carbon ring cleavage
  作者：Andrei V. Bekish、Oleg G. Kulinkovich

  DOI：10.1016/j.tetlet.2005.08.076

  日期：2005.10

  Ethoxycarbonyl groups in O-THP protected racemic diethyl malate I were differentiated by their reductive cyclopropanation with ethylmagnesium bromide in the presence of titanium(IV) isopropoxide and subsequent site-selective C1-C2, C2-C3 or both C1-C2 and C1-C3 ring cleavage of the cyclopropyl groups of the resulting bis-cyclopropanol 2. (c) 2005 Elsevier Ltd. All rights reserved.