mycosamine | 60426-43-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: mycosamine
• 英文别名: (3S,4S,5S,6R)-4-amino-6-methyltetrahydro-2H-pyran-2,3,5-triol；(3S,4S,5S,6R)-4-amino-6-methyloxane-2,3,5-triol
• CAS: 60426-43-9
• 化学式: C₆H₁₃NO₄
• 分子量: 163.174
• InChiKey: OINCELAOJGBMQV-YIDFTEPTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  95.9
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  SCH-38518 在 盐酸 作用下， 反应 3.0h， 生成 mycosamine 、 (3R,7S,10R,11R)-3,7,11-triethyl-10-hydroxyazacyclotetradecan-2-one
  参考文献：
  名称：

  Sch 38518 and Sch 39185: two novel macrolactam antifungals

  摘要：

  Sch 38518 和 Sch 39185 这两种抗真菌药是从一种普通放线菌亚种的发酵液中分离出来的，根据化学转化和光谱数据，它们的结构被归类为大环内酰胺结构。

  DOI：

  10.1039/c39910000810

文献信息

• NYSTATIN FORMULATION HAVING REDUCED TOXICITY
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：EP1261351A2

  公开（公告）日：2002-12-04
• US6413537B1
  申请人：——

  公开号：US6413537B1

  公开（公告）日：2002-07-02
• [EN] NYSTATIN FORMULATION HAVING REDUCED TOXICITY<br/>[FR] FORMULATION DE NYSTATINE A TOXICITE REDUITE
  申请人：WISCONSIN ALUMNI RES FOUND

  公开号：WO2001068102A2

  公开（公告）日：2001-09-20

  The present invention provides a novel formulation of nystatin for parenteral administration to treat systemic fungal infections. The formulation avoids the toxicity and solubility problems of prior art nystatin formulations.
• [EN] NATAMYCIN COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSITIONS DE NATAMYCINE ET UTILISATIONS DE CELLES-CI
  申请人：AREC CROP PROT B V

  公开号：WO2017183972A1

  公开（公告）日：2017-10-26

  Provided is a particular form of natamycin that shows improved properties as a fungicide for use in agricultural applications. A preferred natamycin composition comprises a structuring agent and a surfactant, Said natamycin composition further comprises cellular matter from a natamycin-producing organism. The natamycin in a natamycin composition preferably has a surface area of less than 6m2/g, and an average particle size of less than 6 micrometer. The invention further relates to methods, comprising contacting a plant or part thereof, a fungus, a fruit, a crop, a seed, and/or a soil with a natamycin composition of the invention.
• Sch 38518 and Sch 39185: two novel macrolactam antifungals
  作者：Vinod R. Hegde、Mahesh G. Patel、Vincent P. Gullo、Mohindar S. Puar

  DOI：10.1039/c39910000810

  日期：——

  The structures of Sch 38518 and Sch 39185, two antifungals isolated from the fermentation broth of an Actinomadura vulgaris subsp. vulgaris, have been assigned as macrocyclic lactam structures based on chemical transformations and spectroscopic data.

  Sch 38518 和 Sch 39185 这两种抗真菌药是从一种普通放线菌亚种的发酵液中分离出来的，根据化学转化和光谱数据，它们的结构被归类为大环内酰胺结构。