2-(1,3-苯并二氧戊环-5-基)-3-甲氧基-吡喃并[6,5-e][1]苯并呋喃-4-酮 | 481-99-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 2-(1,3-苯并二氧戊环-5-基)-3-甲氧基-吡喃并[6,5-e][1]苯并呋喃-4-酮
• 英文名称: pongapin
• 英文别名: 2-(1,3-benzodioxol-5-yl)-3-methoxyfuro[2,3-h]chromen-4-one
• CAS: 481-99-2
• 化学式: C₁₉H₁₂O₆
• 分子量: 336.301
• InChiKey: IGFBIJDAWSAJIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  67.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  胡椒酸 在 吡啶 、 氯化亚砜 、 乙醚 、 3,4-methylenedioxybenzoic acid sodium salt 作用下， 生成 2-(1,3-苯并二氧戊环-5-基)-3-甲氧基-吡喃并[6,5-e][1]苯并呋喃-4-酮
  参考文献：
  名称：

  Row, Australian Journal of Scientific Research, Series A: Physical Sciences, 1952, vol. 5, p. 754,758

  摘要：

  DOI：

文献信息

• Synthesis of benzo-furan derivatives-I
  作者：R. Aneja、S.K. Mukerjee、T.R. Seshadri

  DOI：10.1016/0040-4020(58)88041-2

  日期：1958.5

  A new method of preparing benzo-furan derivatives using substituted allyl phenols has been worked out. Ozonolysis of the allyl derivatives and subsequent ring closure of the resulting o-hydroxy-acetaldehydes by means of o-phosphoric acid give good yields of karanj ketone, karanjin, pongapin and the corresponding 2-methyl furanochromone. As an alternative route oxidation of the allyl phenol in two stages

  已经研究出一种使用取代的烯丙基苯酚制备苯并呋喃衍生物的新方法。烯丙基衍生物的臭氧分解和随后通过邻磷酸对所得的邻羟基-乙醛的闭环反应产生了良好的卡拉尼酮，卡拉然，pongapin和相应的2-甲基呋喃色酮的收率。作为替代途径，烯丙基苯酚在先进行酸继之以高碘酸的两步氧化反应已成功地用于合成甘兰胶。
• Scandium-Catalyzed Phenol-Directed Construction of 5-Carbonyl-4-hydroxybenzofurans via Intramolecular Friedel–Crafts Reaction
  作者：Takahito Kuribara、Ayahito Kaneki、Yuma Mihara、Honoka Yuba、Tetsuhiro Nemoto

  DOI：10.1021/acs.orglett.3c03123

  日期：2023.11.3

  5-carbonyl-4-hydroxybenzofurans via a phenol-directed intramolecular Friedel–Crafts reaction. This synthetic method was applied for the total synthesis of furanoflavones. Experimental studies and density functional theory calculations suggest that hydrogen bond interactions between the phenolic hydroxy group and the scandium complex realize regioselective intramolecular cyclization.

  在此，我们报道了通过苯酚引导的分子内弗里德尔-克来福特反应，钪催化的5-羰基-4-羟基苯并呋喃的区域选择性合成。该合成方法应用于呋喃黄酮的全合成。实验研究和密度泛函理论计算表明，酚羟基与钪配合物之间的氢键相互作用实现了区域选择性分子内环化。
• Cosmetic composition comprising a combination of pongamia oil and 4-t-butylcyclohexanol for the treatment of rosacea
  申请人：PIERRE FABRE DERMO-COSMETIQUE

  公开号：US10765641B2

  公开（公告）日：2020-09-08

  The present invention relates to the novel combination of pongamia oil and 4-t-butylcyclohexanol, and to the uses thereof in the fields of cosmetics and dermatology to combat redness. More specifically, the present invention relates to the cosmetic use of a composition comprising said combination to combat rosacea.

  本发明涉及庞加莱油和 4-t-丁基环己醇的新型组合物，以及其在化妆品和皮肤病学领域防治红斑痤疮的用途。 更具体地说，本发明涉及一种包含上述组合物的组合物的化妆品用途，以防治酒渣鼻。
• PONGAMIA COMPOSITIONS, METHODS OF PREPARING AND ANALYZING THEREOF, AND USES THEREOF
  申请人：Terviva Bioenergy, Inc.

  公开号：EP3860358A1

  公开（公告）日：2021-08-11
• COSMETIC COMPOSITION COMPRISING A COMBINATION OF PONGAMIA OIL AND 4-T-BUTYLCYCLOHEXANOL FOR THE TREATMENT OF ROSACEA
  申请人：PIERRE FABRE DERMO-COSMETIQUE

  公开号：US20190350875A1

  公开（公告）日：2019-11-21

  The present invention relates to the novel combination of pongamia oil and 4-t-butylcyclohexanol, and to the uses thereof in the fields of cosmetics and dermatology to combat redness. More specifically, the present invention relates to the cosmetic use of a composition comprising said combination to combat rosacea.