U 0124 | 108923-79-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: U 0124
• 英文别名: 1,4-Diamino-1,4-bismethylthio-butadien-2,3-dicarbonitril；2,3-bis-(amino-methylsulfanyl-methylene)-succinonitrile；2,3-Bis-(amino-methylmercapto-methylen)-succinonitril；1,4-Diamino-2,3-dicyano-1,4-bis(methylthio)butadiene；(2Z,3Z)-2,3-bis[amino(methylsulfanyl)methylidene]butanedinitrile
• CAS: 108923-79-1
• 化学式: C₈H₁₀N₄S₂
• 分子量: 226.326
• InChiKey: LBQNBMSPTURKGS-KQQUZDAGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  150
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  U 0124 在 盐酸 、 乙醇 作用下， 生成 2,5-bis-methylsulfanyl-pyrrole-3,4-dicarbonitrile
  参考文献：
  名称：

  Cyanocarbon Chemistry. VIII.¹ Heterocyclic Compounds from Tetracyanoethylene

  摘要：

  DOI：

  10.1021/ja01544a058
• 作为产物：
  描述：

  2,5-Diamino-4-cyan-thiophen-3-thiocarboxamid 、 碘甲烷 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 0.25h， 以58%的产率得到U 0124
  参考文献：
  名称：

  Gewald, K.; Schindler, R., Journal fur praktische Chemie (Leipzig 1954), 1990, vol. 332, # 2, p. 223 - 228

  摘要：

  DOI：

文献信息

• METHOD FOR THE SELECTION OF MODULATORS OF BDNF
  申请人：Universita' Degli Studi di Trieste

  公开号：EP2638175B1

  公开（公告）日：2017-05-17
• COMPOSITIONS AND METHODS FOR TREATING SKIN CANCER ASSOCIATED DISEASES
  申请人：The Trustees of the University of Pennsylvania

  公开号：US20130178440A1

  公开（公告）日：2013-07-11

  The invention provides compositions and methods for treating skin cancer associated diseases. Specifically, the invention relates to topically administering a signaling pathway inhibitor or a related compound to treat pre-cancerous skin lesions, skin tumors, and their associated diseases or disorders.
• METHOD FOR THE SELECTION OF COMPOUNDS USEFUL FOR THE TREATMENT OF PSYCHIATRIC AND NEURODEGENERATIVE DISEASES
  申请人：Tongiorgi Enrico

  公开号：US20130224754A1

  公开（公告）日：2013-08-29

  The present invention concerns a method for the identification of specific compounds which modulate brain-derived neurotrophic factor, which can be used as drugs for the treatment of neurological and neuropsychiatric diseases and which are suitable for the treatment of deleterious effects caused to the nervous system by abuse of illegal or legal drugs.
• DIFFERENTIATION OF CORTICAL NEURONS FROM HUMAN PLURIPOTENT STEM CELLS
  申请人：MEMORIAL SLOAN-KETTERING CANCER CENTER

  公开号：US20180346875A1

  公开（公告）日：2018-12-06

  The presently disclosed subject matter provides for in vitro methods of inducing differentiation of human stem cells into cortical neurons, and cortical neurons generated by such methods. The presently disclosed subject matter also provides for uses of such cortical neurons for treating neurodegenerative CNS disorders.
• US9084790B2
  申请人：——

  公开号：US9084790B2

  公开（公告）日：2015-07-21