5,3'-dihydroxy-6,7,4'-trimethoxyflavanone | 111670-59-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 5,3'-dihydroxy-6,7,4'-trimethoxyflavanone
• 英文别名: 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,7-dimethoxy-2,3-dihydrochromen-4-one
• CAS: 111670-59-8
• 化学式: C₁₈H₁₈O₇
• 分子量: 346.337
• InChiKey: PSQNZFFDWLQECV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  94.4
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  5,3'-dihydroxy-6,7,4'-trimethoxyflavanone 、 乙酸酐 生成 [5-(5-acetyloxy-6,7-dimethoxy-4-oxo-2,3-dihydrochromen-2-yl)-2-methoxyphenyl] acetate
  参考文献：
  名称：

  CHANDRA, S.;BABBER, SUNANDA, INDIAN J. CHEM., 26,(1987) N 1, 82-84

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3,4-三甲氧基-6-羟基苯乙酮 在 三氯化铝 、 硫酸 作用下， 以 乙醇 、 乙腈 为溶剂， 反应 10.0h， 生成 5,3'-dihydroxy-6,7,4'-trimethoxyflavanone
  参考文献：
  名称：

  Chandra, S.; Babber, Sunanda, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1987, vol. 26, p. 82 - 84

  摘要：

  DOI：

文献信息

• Hepatoprotective activity of 2'-p-hydroxybenzoylmussaenosidic
  申请人：——

  公开号：US20040014684A1

  公开（公告）日：2004-01-22

  The present invention provides a method for treating and/or preventing hepatic disease conditions in a subject mammals including human beings, said method comprising the steps of administering to the mammal an effective dosage of composition comprising 2′-p-Hydroxy benzoyl mussaenosidic acid from plant Vitex negundo optionally as individual or in combination with one or more pharmaceutically additives.

  本发明提供了一种用于治疗和/或预防哺乳动物，包括人类的肝病状况的方法，该方法包括向哺乳动物施用包含来自牛蒡树植物的2'-p-羟基苯甲酰木鳖苷酸的有效剂量组合物，可选地与一个或多个药物添加剂单独或组合使用的步骤。
• HEPATOPROTECTIVE ACTIVITY OF 10-O-P-HYDROXYBENZOYIAUCUBIN
  申请人：Council Of Scientific And Industrial Research

  公开号：EP1509223A1

  公开（公告）日：2005-03-02
• HEPATOPROTECTIVE ACTIVITY OF 2 -P-HYDROXYBENZOYLMUSSAENOSIDIC ACID
  申请人：Council of Scientific andIndustrial Research

  公开号：EP1503773A1

  公开（公告）日：2005-02-09
• Hepatoprotective activity of 10-O-P-hydroxybenzoyiaucubin
  申请人：——

  公开号：US20040029816A1

  公开（公告）日：2004-02-12

  A method for treating and/or preventing hepatic disease conditions in mammals including human beings, said method comprising the steps of administering to the mammal an effective amount of 10-O-p-hydroxybenzoylaucubin compound of Formula 1, also called Agnuside, optionally individual or in combination with one or more pharmaceutically acceptable additives.
• AGENT CONTAINING FLAVONOID DERIVATIVES FOR TREATING CANCER AND INFLAMMATION
  申请人：Lowe Henry

  公开号：US20170360744A1

  公开（公告）日：2017-12-21

  A pharmaceutical composition for the prevention and treatment of cancer with specific flavanoid-based compounds selected from among the groups of Flavone, Flavanone and Flavanol, a method for the prevention and treatment of cancer and inflammation using the specific flavonoid-based pharmaceutical compositions, a method for isolating the flavonoid-based pharmaceutical compositions from raw plant material, and a method for synthesizing said specific flavonoid-based pharmaceutical compositions.